Tchem PHOSPHO1 Phosphoethanolamine/phosphocholine phosphatase

Protein Summary

Description

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

Uniprot Accession IDs

• Q8TCT1
• E9PAM0
• Q17RU6

Gene Name

• PHOSPHO1

Ensembl ID

• ENST00000310544
• ENSP00000311925
• ENSG00000173868
• ENST00000413580
• ENSP00000406909
• ENST00000514112
• ENSP00000427694

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
transcription factor	0.67
phenotype	0.65
tissue sample	0.62
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphoethanolamine/phosphocholine Phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphoethanolamine/phosphocholine Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.21   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.21   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1