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Tchem
PHLPP1
PH domain leucine-rich repeat-containing protein phosphatase 1

Protein Summary
Description
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262719
  • ENSP00000262719
  • ENSG00000081913

Symbol
  • KIAA0606
  • PHLPP
  • PLEKHE1
  • SCOP
  • SCOP
  • PHLPP
  • PPM3A
  • PLEKHE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
kinase perturbation
0.88
disease perturbation
0.87
transcription factor binding site profile
0.86
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.2   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.2   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (124)
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999999091
p_ni:  9.09e-7
Data Source:  BioPlex
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.999989802
p_ni:  0.000010186
p_wrong:  1.2e-8
Score:  0.835
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.996554616
p_ni:  0.003443909
p_wrong:  0.000001475
Score:  0.337
Data Source:  BioPlex,STRINGDB
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.994782943
p_ni:  0.005216017
p_wrong:  0.00000104
Score:  0.15
Data Source:  BioPlex,STRINGDB
USP1
Tchem
Family:  Enzyme
Novelty:  0.0092606
p_int:  0.943165926
p_ni:  0.056831754
p_wrong:  0.00000232
Score:  0.606
Data Source:  BioPlex,STRINGDB
RFPL2
Tdark
Novelty:  1.87914964
p_int:  0.911673559
p_ni:  0.076313421
p_wrong:  0.01201302
Score:  0.227
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.883000579
p_ni:  0.087267034
p_wrong:  0.029732387
Score:  0.272
Data Source:  BioPlex,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.991
Data Source:  Reactome,STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
Score:  0.985
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.976
Data Source:  STRINGDB
Pathways (36)
Intracellular signaling by second messengers (R-HSA-9006925)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PIP3 activates AKT signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Negative regulation of the PI3K/AKT network
PIP3 activates AKT signaling
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
55.2
inflammatory biomarker measurement
1
1
0
46.6
7.6
body mass index
1
1
1
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
55.2
inflammatory biomarker measurement
0
46.6
7.6
body mass index
1
7.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PH domain and leucine rich repeat protein phosphatase 1
VGNC:13275
468563
Macaque
PH domain and leucine rich repeat protein phosphatase 1
705882
Mouse
MGI:2138327
98432
Rat
RGD:621308
59265
Dog
PH domain and leucine rich repeat protein phosphatase 1
VGNC:44504
476179
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PH domain and leucine rich repeat protein phosphatase 1
Macaque
PH domain and leucine rich repeat protein phosphatase 1
Mouse
Rat
Dog
PH domain and leucine rich repeat protein phosphatase 1
Publication Statistics
PubMed Score 156.20
PubMed score by year
PubTator Score 109.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title