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Tdark
PHLDB3
Pleckstrin homology-like domain family B member 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292140
  • ENSP00000292140
  • ENSG00000176531
  • ENST00000599242
  • ENSP00000471158
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
cellular component
0.58
cell line
0.57
histone modification site profile
0.53
gene perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.88   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.88   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999466776
p_ni:  0.000533224
Data Source:  BioPlex
CRHBP
Tbio
Novelty:  0.00726484
p_int:  0.999062182
p_ni:  0.000937818
Score:  0.183
Data Source:  BioPlex,STRINGDB
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.997283202
p_ni:  0.002716798
Data Source:  BioPlex
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.996528641
p_ni:  0.003471359
Data Source:  BioPlex
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.996354264
p_ni:  0.003645736
Data Source:  BioPlex
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.994881854
p_ni:  0.005118146
Data Source:  BioPlex
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.99455089
p_ni:  0.00544911
Data Source:  BioPlex
TMEM52B
Tdark
Novelty:  1.55824039
p_int:  0.989021308
p_ni:  0.010978692
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.986034623
p_ni:  0.013965377
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.974147929
p_ni:  0.025852071
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
2
2
71.4
low density lipoprotein cholesterol measurement
3
3
3
68.9
body height
1
1
1
42.4
appendicular lean mass
1
1
1
33.8
platelet count
1
1
1
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
71.4
low density lipoprotein cholesterol measurement
3
68.9
body height
1
42.4
appendicular lean mass
1
33.8
platelet count
1
25.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology like domain family B member 3
VGNC:13306
104003390
Mouse
MGI:3642959
232970
Rat
RGD:1561121
308431
Dog
pleckstrin homology like domain family B member 3
VGNC:44503
484470
Horse
pleckstrin homology like domain family B member 3
VGNC:51061
100070137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology like domain family B member 3
Mouse
Rat
Dog
pleckstrin homology like domain family B member 3
Horse
pleckstrin homology like domain family B member 3
Publication Statistics
PubMed Score 0.88
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title