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Tchem
PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Protein Summary
Description
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424889
  • ENSP00000388571
  • ENSG00000156873
  • ENST00000563588
  • ENSP00000455607

Symbol
  • GSD9C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
kinase perturbation
0.81
disease perturbation
0.74
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (60)
PHKA1
Tbio
Family:  Kinase
Novelty:  0.02895127
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
PHKG1
Tchem
Family:  Kinase
Novelty:  0.08576384
p_int:  1
Score:  0.876
Data Source:  BioPlex,STRINGDB
PHKA2
Tbio
Family:  Kinase
Novelty:  0.00461145
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PHKB
Tbio
Family:  Enzyme
Novelty:  0.05506418
p_int:  0.999999994
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999998861
p_ni:  0.000001139
Score:  0.554
Data Source:  BioPlex,STRINGDB
CEP85L
Tbio
Novelty:  0.23631446
p_int:  0.999997406
p_ni:  0.000002348
p_wrong:  2.47e-7
Score:  0.239
Data Source:  BioPlex,STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.999937294
p_ni:  0.000062706
Score:  0.708
Data Source:  BioPlex,STRINGDB
DOK4
Tbio
Novelty:  0.06349482
p_int:  0.999848918
p_ni:  0.000132883
p_wrong:  0.000018199
Score:  0.321
Data Source:  BioPlex,STRINGDB
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.999808391
p_ni:  0.000136402
p_wrong:  0.000055207
Data Source:  BioPlex
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.999787334
p_ni:  0.000191702
p_wrong:  0.000020964
Score:  0.258
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (19)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
67.1
testosterone measurement
2
2
2
46.5
HMG CoA reductase inhibitor use measurement
1
1
1
33.1
1
1
0
1.1
12.9
IGF-1 measurement
1
1
1
9.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
67.1
testosterone measurement
2
46.5
HMG CoA reductase inhibitor use measurement
1
33.1
0
1.1
12.9
IGF-1 measurement
1
9.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase catalytic subunit gamma 2
VGNC:9390
741602
Macaque
phosphorylase kinase catalytic subunit gamma 2
100423096
Mouse
MGI:1916211
68961
Rat
RGD:620024
140671
Dog
phosphorylase kinase catalytic subunit gamma 2
VGNC:44500
607275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase catalytic subunit gamma 2
Macaque
phosphorylase kinase catalytic subunit gamma 2
Mouse
Rat
Dog
phosphorylase kinase catalytic subunit gamma 2
Publication Statistics
PubMed Score 16.48
PubMed score by year
PubTator Score 11.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title