PHKG1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Protein Summary
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- ENST00000297373
- ENSP00000297373
- ENSG00000164776
- ENST00000452681
- ENSP00000445440
- PHKG
- PHKG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
protein domain | 0.92 | ||
cell type or tissue | 0.76 | ||
gene perturbation | 0.75 | ||
PubMedID | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.28 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 289 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.28 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 289 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (5)
Protein-Protein Interactions (52)
Nearest Tclin Targets (6)
Upstream (3)
Downstream (3)
1 – 3 of 3
Pathways (9)
Reactome (4)
KEGG (3)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glycogen breakdown (glycogenolysis) | ||||
Reactome | Glycogen metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glycogen breakdown (glycogenolysis) | ||||
Glycogen metabolism | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (6)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
amino acid measurement | 3 | 11 | 19 | 94.4 | |||||
glycine measurement | 3 | 2 | 3 | 90.8 | |||||
blood metabolite measurement | 2 | 1 | 2 | 69.8 | |||||
myeloid white cell count | 1 | 1 | 1 | 66.3 | |||||
lymphocyte count | 1 | 1 | 1 | 64.9 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
amino acid measurement | 19 | 94.4 | |||||
glycine measurement | 3 | 90.8 | |||||
blood metabolite measurement | 2 | 69.8 | |||||
myeloid white cell count | 1 | 66.3 | |||||
lymphocyte count | 1 | 64.9 | |||||
Find similar targets by:
IDG Resources
Data Resources (2)
NanoBRET
- Institute: UNC-CH
- Authors: Julie Pickett
- PI: Tim Willson
- Assay ID: BAO_0010069
- Endpoint: fold change
- Endpoint Detection: fluorescence intensity
- Repository: Synapse
NanoBRET
- Institute: UNC-CH
- Authors: Julie Pickett
- PI: Tim Willson
- Assay ID: BAO_0010069
- Endpoint: fold change
- Endpoint Detection: fluorescence intensity
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphorylase kinase catalytic subunit gamma 1 | VGNC:9067 | 746486 | |||||
Macaque | phosphorylase kinase catalytic subunit gamma 1 | 703091 | ||||||
Mouse | MGI:97579 | 18682 | ||||||
Rat | RGD:3325 | 29353 | ||||||
Dog | phosphorylase kinase catalytic subunit gamma 1 | VGNC:44499 | 489784 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphorylase kinase catalytic subunit gamma 1 | |||||
Macaque | phosphorylase kinase catalytic subunit gamma 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphorylase kinase catalytic subunit gamma 1 | |||||
Publication Statistics
PubMed Score 11.28
PubMed score by year
PubTator Score 5.25
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (25)
Items per page:
0 of 0
PMID | Year | Title |
|---|