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Tbio
PHKA2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

Protein Summary
Description
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379942
  • ENSP00000369274
  • ENSG00000044446

Symbol
  • PHKLA
  • PYK
  • PHK
  • PYK
  • XLG
  • PYKL
  • XLG2
  • GSD9A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
virus perturbation
0.9
kinase perturbation
0.88
protein domain
0.58
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.91   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.91   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.702
Data Source:  BioPlex,STRINGDB
DOK4
Tbio
Novelty:  0.06349482
p_int:  0.999864351
p_ni:  0.0001356
p_wrong:  4.9e-8
Score:  0.734
Data Source:  BioPlex,STRINGDB
TCEANC2
Tdark
Novelty:  0.40325323
p_int:  0.998286037
p_ni:  0.001700811
p_wrong:  0.000013152
Score:  0.734
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.941930997
p_ni:  0.057208265
p_wrong:  0.000860737
Data Source:  BioPlex
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.818306209
p_ni:  0.159193125
p_wrong:  0.022500666
Data Source:  BioPlex
PHKG1
Tchem
Family:  Kinase
Novelty:  0.08576384
Score:  0.975
Data Source:  STRINGDB
PHKB
Tbio
Family:  Enzyme
Novelty:  0.05506418
Score:  0.965
Data Source:  Reactome,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.953
Data Source:  Reactome,STRINGDB
PYGL
Tchem
Family:  Enzyme
Novelty:  0.01157477
Score:  0.944
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (11)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase regulatory subunit alpha 2
VGNC:10404
465523
Macaque
phosphorylase kinase regulatory subunit alpha 2
694376
Mouse
MGI:97577
110094
Dog
phosphorylase kinase regulatory subunit alpha 2
VGNC:44497
480857
Horse
phosphorylase kinase regulatory subunit alpha 2
VGNC:21391
100051530
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase regulatory subunit alpha 2
Macaque
phosphorylase kinase regulatory subunit alpha 2
Mouse
Dog
phosphorylase kinase regulatory subunit alpha 2
Horse
phosphorylase kinase regulatory subunit alpha 2
Publication Statistics
PubMed Score 238.91
PubMed score by year
PubTator Score 133.57
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title