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Tbio
PHF6
PHD finger protein 6

Protein Summary
Description
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by cognitive disability, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332070
  • ENSP00000329097
  • ENSG00000156531
  • ENST00000370800
  • ENSP00000359836
  • ENST00000370803
  • ENSP00000359839

Symbol
  • CENP-31
  • KIAA1823
  • BFLS
  • BORJ
  • CENP-31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
microRNA
0.79
molecular function
0.79
cellular component
0.7
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.21   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.21   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.818685058
p_ni:  0.181314942
Data Source:  BioPlex
TLX3
Tbio
Family:  TF
Novelty:  0.01152722
Score:  0.761
Data Source:  STRINGDB
YIPF6
Tdark
Novelty:  0.04316252
Score:  0.712
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.69
Data Source:  STRINGDB
PLAC1
Tbio
Novelty:  0.01213036
Score:  0.681
Data Source:  STRINGDB
ASXL1
Tbio
Family:  Epigenetic
Novelty:  0.00342965
Score:  0.672
Data Source:  STRINGDB
NPM1
Tbio
Novelty:  0.0005485
Score:  0.667
Data Source:  STRINGDB
TLX1
Tbio
Family:  TF
Novelty:  0.00619542
Score:  0.667
Data Source:  STRINGDB
STAG2
Tbio
Novelty:  0.00430441
Score:  0.652
Data Source:  STRINGDB
NOTO
Tdark
Family:  TF
Novelty:  0.13103606
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
27.5
calcium measurement
1
1
1
25.8
hematocrit
1
1
1
3.1
hemoglobin measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
27.5
calcium measurement
1
25.8
hematocrit
1
3.1
hemoglobin measurement
1
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 6
707390
Mouse
MGI:1918248
70998
Rat
RGD:2323526
100359714
Dog
PHD finger protein 6
VGNC:44492
612921
Horse
PHD finger protein 6
VGNC:21385
100054177
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 6
Mouse
Rat
Dog
PHD finger protein 6
Horse
PHD finger protein 6
Publication Statistics
PubMed Score 166.21
PubMed score by year
PubTator Score 76.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title