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Tbio
PHF5A
PHD finger-like domain-containing protein 5A

Protein Summary
Description
Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216252
  • ENSP00000216252
  • ENSG00000100410

Symbol
  • INI
  • Rds3
  • SF3B7
  • SAP14b
  • SF3b14b
  • bK223H9.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
transcription factor binding site profile
0.88
histone modification site profile
0.86
disease perturbation
0.68
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (313)
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.999999935
p_ni:  6.4e-8
p_wrong:  1e-9
Score:  0.919
Data Source:  BioPlex,STRINGDB
ZMAT5
Tdark
Novelty:  0.97115324
p_int:  0.999999929
p_ni:  5.6e-8
p_wrong:  1.5e-8
Score:  0.775
Data Source:  BioPlex,STRINGDB
TTC33
Tdark
Novelty:  0.31237949
p_int:  0.999999853
p_ni:  1.26e-7
p_wrong:  2.1e-8
Data Source:  BioPlex
SNRNP48
Tbio
Novelty:  0.16395917
p_int:  0.999999819
p_ni:  1.62e-7
p_wrong:  1.8e-8
Score:  0.72
Data Source:  BioPlex,STRINGDB
PDCD7
Tbio
Novelty:  0.15531712
p_int:  0.99999971
p_ni:  2.9e-7
Score:  0.72
Data Source:  BioPlex,STRINGDB
SLC4A1AP
Tdark
Family:  Transporter
Novelty:  0.41125302
p_int:  0.999999467
p_ni:  5.32e-7
Data Source:  BioPlex
SNRNP35
Tdark
Novelty:  1.00002211
p_int:  0.999999443
p_ni:  2.38e-7
p_wrong:  3.19e-7
Score:  0.89
Data Source:  BioPlex,STRINGDB
RNPC3
Tbio
Novelty:  0.07154673
p_int:  0.999999161
p_ni:  8.31e-7
p_wrong:  8e-9
Score:  0.973
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.999996428
p_ni:  0.000003571
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
p_int:  0.999994768
p_ni:  0.000005232
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
84.1
lymphocyte percentage of leukocytes
2
2
2
81.7
IGF-1 measurement
1
1
1
73.9
3
3
0
1.1
68.5
2
2
0
1.3
68.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
84.1
lymphocyte percentage of leukocytes
2
81.7
IGF-1 measurement
1
73.9
0
1.1
68.5
0
1.3
68.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 5A
VGNC:5294
745456
Macaque
PHD finger protein 5A
711683
Mouse
MGI:2156864
68479
Rat
RGD:621555
192246
Dog
PHD finger protein 5A
VGNC:44491
474489
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 5A
Macaque
PHD finger protein 5A
Mouse
Rat
Dog
PHD finger protein 5A
Publication Statistics
PubMed Score 42.05
PubMed score by year
PubTator Score 75.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title