Tbio PHF23 PHD finger protein 23

Protein Summary

Description

Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.

Uniprot Accession IDs

• Q9BUL5
• A1DZ74
• B3KVH8
• B4DLK6
• D3DTN4
• Q8IZK0
• Q96HG7
• Q9H5X0

Gene Name

• PHF23

Ensembl ID

• ENST00000320316
• ENSP00000322579
• ENSG00000040633
• ENST00000454255
• ENSP00000414607
• ENST00000571362
• ENSP00000460738

Symbol

• hJUNE-1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
disease perturbation	0.96
kinase perturbation	0.91
transcription factor binding site profile	0.89
transcription factor	0.81

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Plant Homeodomain / Phd Finger Protein 23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

HCCS

Tbio

Family:  Enzyme

Novelty:  0.0022585

p_int:  0.999991559

p_ni:  0.00000844

Score:  0.252

Data Source:  BioPlex,STRINGDB

ATXN7L1

Tdark

Novelty:  0.43694835

p_int:  0.999682861

p_ni:  0.000006652

p_wrong:  0.000310488

Data Source:  BioPlex

SIN3A

Tbio

Novelty:  0.00747207

p_int:  0.999286649

p_ni:  0.000713351

Score:  0.715

Data Source:  BioPlex,STRINGDB

SAP130

Tdark

Family:  Enzyme

Novelty:  1.85084032

p_int:  0.990352281

p_ni:  0.009647691

p_wrong:  2.8e-8

Score:  0.188

Data Source:  BioPlex,STRINGDB

ARID4B

Tbio

Family:  TF; Epigenetic

Novelty:  0.04182223

p_int:  0.989808949

p_ni:  0.010191051

Score:  0.393

Data Source:  BioPlex,STRINGDB

SIN3B

Tbio

Novelty:  0.04097105

p_int:  0.979856

p_ni:  0.020143992

p_wrong:  8e-9

Score:  0.771

Data Source:  BioPlex,STRINGDB

SAP30

Tbio

Family:  Enzyme

Novelty:  0.03474176

p_int:  0.958566718

p_ni:  0.041316914

p_wrong:  0.000116368

Score:  0.305

Data Source:  BioPlex,STRINGDB

SUDS3

Tbio

Family:  Enzyme

Novelty:  0.03837881

p_int:  0.953725838

p_ni:  0.046274159

p_wrong:  3e-9

Score:  0.857

Data Source:  BioPlex,STRINGDB

BRMS1L

Tbio

Novelty:  0.01578276

p_int:  0.894788857

p_ni:  0.10509136

p_wrong:  0.000119783

Score:  0.389

Data Source:  BioPlex,STRINGDB

KDM5A

Tchem

Family:  TF; Epigenetic

Novelty:  0.00953355

Score:  0.71

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (2)

Components (3)

Processes (5)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (39)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 39

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	4	7	6	15.8	99.5
apolipoprotein B measurement	EFO_0004615	2	6	7		97.8
low density lipoprotein cholesterol measurement	EFO_0004611	7	5	12		97.1
total cholesterol measurement	EFO_0004574	4	4	8		95.8
birth weight	EFO_0004344	4	3	4		89.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 39

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	6	15.8	99.5
apolipoprotein B measurement	EFO_0004615	7		97.8
low density lipoprotein cholesterol measurement	EFO_0004611	12		97.1
total cholesterol measurement	EFO_0004574	8		95.8
birth weight	EFO_0004344	4		89.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Autophagy
Chromosomal rearrangement
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
autoimmune thyroid disease
birth weight
body height at birth
C-reactive protein measurement
diastolic blood pressure
Diuretic use measurement
eosinophil count

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PHD finger protein 23	VGNC:9515	455235
Macaque	PHD finger protein 23		714538
Mouse	PHD finger protein 23	MGI:1925496	78246
Rat	PHD finger protein 23	RGD:1302969	360550
Dog	PHD finger protein 23	VGNC:44488	489465

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PHD finger protein 23
Macaque	PHD finger protein 23
Mouse	PHD finger protein 23
Rat	PHD finger protein 23
Dog	PHD finger protein 23

Publication Statistics

PubMed Score 6.70

PubMed score by year

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PubTator Score 4.08

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title