PHF23
PHD finger protein 23
Protein Summary
Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
- ENST00000320316
- ENSP00000322579
- ENSG00000040633
- ENST00000454255
- ENSP00000414607
- ENST00000571362
- ENSP00000460738
- hJUNE-1b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.89 | ||
transcription factor | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.41 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 49 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.41 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 49 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0