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Tbio
PHF23
PHD finger protein 23

Protein Summary
Description
Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320316
  • ENSP00000322579
  • ENSG00000040633
  • ENST00000454255
  • ENSP00000414607
  • ENST00000571362
  • ENSP00000460738

Symbol
  • hJUNE-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.96
kinase perturbation
0.91
transcription factor binding site profile
0.89
transcription factor
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.999991559
p_ni:  0.00000844
Score:  0.252
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.999682861
p_ni:  0.000006652
p_wrong:  0.000310488
Data Source:  BioPlex
SIN3A
Tbio
Novelty:  0.00747207
p_int:  0.999286649
p_ni:  0.000713351
Score:  0.715
Data Source:  BioPlex,STRINGDB
SAP130
Tdark
Family:  Enzyme
Novelty:  1.85084032
p_int:  0.990352281
p_ni:  0.009647691
p_wrong:  2.8e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
ARID4B
Tbio
Family:  TF; Epigenetic
Novelty:  0.04182223
p_int:  0.989808949
p_ni:  0.010191051
Score:  0.393
Data Source:  BioPlex,STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
p_int:  0.979856
p_ni:  0.020143992
p_wrong:  8e-9
Score:  0.771
Data Source:  BioPlex,STRINGDB
SAP30
Tbio
Family:  Enzyme
Novelty:  0.03474176
p_int:  0.958566718
p_ni:  0.041316914
p_wrong:  0.000116368
Score:  0.305
Data Source:  BioPlex,STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
p_int:  0.953725838
p_ni:  0.046274159
p_wrong:  3e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
BRMS1L
Tbio
Novelty:  0.01578276
p_int:  0.894788857
p_ni:  0.10509136
p_wrong:  0.000119783
Score:  0.389
Data Source:  BioPlex,STRINGDB
KDM5A
Tchem
Family:  TF; Epigenetic
Novelty:  0.00953355
Score:  0.71
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
15.8
99.5
apolipoprotein B measurement
2
6
7
97.8
low density lipoprotein cholesterol measurement
7
5
12
97.1
total cholesterol measurement
4
4
8
95.8
birth weight
4
3
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
15.8
99.5
apolipoprotein B measurement
7
97.8
low density lipoprotein cholesterol measurement
12
97.1
total cholesterol measurement
8
95.8
birth weight
4
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 23
VGNC:9515
455235
Macaque
PHD finger protein 23
714538
Mouse
MGI:1925496
78246
Rat
RGD:1302969
360550
Dog
PHD finger protein 23
VGNC:44488
489465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 23
Macaque
PHD finger protein 23
Mouse
Rat
Dog
PHD finger protein 23
Publication Statistics
PubMed Score 6.70
PubMed score by year
PubTator Score 4.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title