Tbio PHF23 PHD finger protein 23

Protein Summary

Description

Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.

Uniprot Accession IDs

• Q9BUL5
• A1DZ74
• B3KVH8
• B4DLK6
• D3DTN4
• Q8IZK0
• Q96HG7
• Q9H5X0

Gene Name

• PHF23

Ensembl ID

• ENST00000320316
• ENSP00000322579
• ENSG00000040633
• ENST00000454255
• ENSP00000414607
• ENST00000571362
• ENSP00000460738

Symbol

• hJUNE-1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
disease perturbation	0.96
kinase perturbation	0.91
transcription factor binding site profile	0.89
transcription factor	0.81

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Plant Homeodomain / Phd Finger Protein 23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0