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Tbio
PHF23
PHD finger protein 23

Protein Summary
Description
Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320316
  • ENSP00000322579
  • ENSG00000040633
  • ENST00000454255
  • ENSP00000414607
  • ENST00000571362
  • ENSP00000460738

Symbol
  • hJUNE-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.96
kinase perturbation
0.91
transcription factor binding site profile
0.89
transcription factor
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0