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Tbio
PHF21A
PHD finger protein 21A

Protein Summary
Description
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323180
  • ENSP00000323152
  • ENSG00000135365
  • ENST00000418153
  • ENSP00000398824

Symbol
  • BHC80
  • KIAA1696
  • BHC80
  • BM-006
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.91
disease perturbation
0.83
transcription factor binding site profile
0.78
cell type or tissue
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999999993
p_ni:  7e-9
Score:  0.885
Data Source:  BioPlex,STRINGDB
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  0.999999914
p_ni:  8.6e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999995624
p_ni:  0.000004375
p_wrong:  1e-9
Score:  0.978
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999931948
p_ni:  0.000068051
p_wrong:  1e-9
Score:  0.153
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999897975
p_ni:  0.000101996
p_wrong:  2.9e-8
Data Source:  BioPlex
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
Score:  0.993
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.98
Data Source:  STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.962
Data Source:  STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
Score:  0.958
Data Source:  STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDACs deacetylate histones
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Factors involved in megakaryocyte development and platelet production
HDACs deacetylate histones
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
2
2
91.9
high density lipoprotein cholesterol measurement
3
3
4
88.7
body height
3
4
4
84.8
fasting blood glucose measurement
6
1
6
77.9
body mass index
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
91.9
high density lipoprotein cholesterol measurement
4
88.7
body height
4
84.8
fasting blood glucose measurement
6
77.9
body mass index
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 21A
VGNC:13323
451152
Macaque
PHD finger protein 21A
714798
Mouse
MGI:2384756
192285
Rat
RGD:1560612
362166
Dog
PHD finger protein 21A
VGNC:44487
483637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 21A
Macaque
PHD finger protein 21A
Mouse
Rat
Dog
PHD finger protein 21A
Publication Statistics
PubMed Score 17.28
PubMed score by year
PubTator Score 6.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title