Tbio PHF20 PHD finger protein 20

Protein Summary

Description

Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.

Uniprot Accession IDs

• Q9BVI0
• A7E235
• B2RB56
• E1P5S3
• Q566Q2
• Q5JWY9
• Q66K49
• Q9BWV4
• Q9BXA3
• Q9BZW3
• Q9H421
• Q9H4J6
• Q9NZ22

Gene Name

• PHF20

Ensembl ID

• ENST00000374012
• ENSP00000363124
• ENSG00000025293

Symbol

• C20orf104
• GLEA2
• HCA58
• NZF
• TZP
• NZF
• TZP
• GLEA2
• HCA58
• TDRD20A
• C20orf104

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.99
virus perturbation	0.95
kinase perturbation	0.91
molecular function	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.34   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.34   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0