Tbio PHF19 PHD finger protein 19

Protein Summary

Description

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.

Uniprot Accession IDs

• Q5T6S3
• Q32NF2
• Q5T6S4
• Q6N038
• Q8TBL6
• Q9UFS9

Gene Name

• PHF19

Ensembl ID

• ENST00000312189
• ENSP00000310372
• ENSG00000119403
• ENST00000373896
• ENSP00000363003

Symbol

• PCL3
• PCL3
• MTF2L1
• TDRD19B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.88
microRNA	0.85
PubMedID	0.74
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Phd Finger Protein 19

DTO Classes

Protein / Nucleic Acid Binding / Phd Finger Protein 19

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.17   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.17   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (87)

Explore Interacting Targets

1 – 10 of 87

• See Interactions on String-DB

SUZ12

Tbio

Novelty:  0.00402353

p_int:  1

Score:  0.986

Data Source:  BioPlex,Reactome,STRINGDB

EZH2

Tclin

Family:  Epigenetic

Novelty:  0.00052816

p_int:  0.999999896

p_ni:  1.02e-7

p_wrong:  3e-9

Score:  0.992

Data Source:  BioPlex,Reactome,STRINGDB

NRBP2

Tdark

Family:  Kinase

Novelty:  0.28776838

p_int:  0.999999428

p_ni:  5.14e-7

p_wrong:  5.8e-8

Score:  0.235

Data Source:  BioPlex,STRINGDB

EZH1

Tchem

Family:  Epigenetic

Novelty:  0.02636757

p_int:  0.999998633

p_ni:  0.000001349

p_wrong:  1.8e-8

Score:  0.941

Data Source:  BioPlex,STRINGDB

EED

Tchem

Novelty:  0.00615758

p_int:  0.999991034

p_ni:  0.000008966

Score:  0.981

Data Source:  BioPlex,Reactome,STRINGDB

CAMK1

Tchem

Family:  Kinase

Novelty:  0.01239891

p_int:  0.999965841

p_ni:  0.000034159

Score:  0.183

Data Source:  BioPlex,STRINGDB

GTF2F1

Tbio

Novelty:  0.02118098

p_int:  0.999929818

p_ni:  0.000070182

Score:  0.233

Data Source:  BioPlex,STRINGDB

GSTCD

Tbio

Family:  Enzyme

Novelty:  0.11613228

p_int:  0.999851308

p_ni:  0.000110507

p_wrong:  0.000038184

Score:  0.187

Data Source:  BioPlex,STRINGDB

CHAMP1

Tbio

Novelty:  0.09520274

p_int:  0.999561017

p_ni:  0.000438381

p_wrong:  6.02e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

PDLIM5

Tbio

Novelty:  0.0040646

p_int:  0.999555041

p_ni:  0.000444959

Score:  0.179

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Epigenetic regulation of gene expression (R-HSA-212165)

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Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Epigenetic regulation of gene expression	118 targets	R-HSA-212165
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	PRC2 methylates histones and DNA	42 targets	R-HSA-212300

Name	Explore in Pharos	Explore in Source
Epigenetic regulation of gene expression	118 targets	R-HSA-212165
Gene expression (Transcription)	1452 targets	R-HSA-74160
PRC2 methylates histones and DNA	42 targets	R-HSA-212300

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (4)

Components (1)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	2	3		89.1
birth weight	EFO_0004344	4	3	4		77.8
rheumatoid arthritis	EFO_0000685	5	4	2	1.1	77.7
serum non-albumin protein measurement	EFO_0004568	1	1	1		64
myeloid white cell count	EFO_0007988	1	1	1		60.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3		89.1
birth weight	EFO_0004344	4		77.8
rheumatoid arthritis	EFO_0000685	2	1.1	77.7
serum non-albumin protein measurement	EFO_0004568	1		64
myeloid white cell count	EFO_0007988	1		60.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Repeat
Repressor

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
allergy
asthma
birth weight
BMI-adjusted hip circumference
Eczema
eosinophil percentage of leukocytes
high density lipoprotein cholesterol measurement
leukocyte count
lymphocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
homeostasis/metabolism phenotype
reproductive system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	PHD finger protein 19		704050
Mouse	PHD finger protein 19	MGI:1921266	74016
Rat	PHD finger protein 19	RGD:1310390	296653
Horse	PHD finger protein 19	VGNC:21378	100071777
Cow	PHD finger protein 19	VGNC:32817	532056

Species	Name	OMA	EggNOG	Inparanoid
Macaque	PHD finger protein 19
Mouse	PHD finger protein 19
Rat	PHD finger protein 19
Horse	PHD finger protein 19
Cow	PHD finger protein 19

Publication Statistics

PubMed Score 54.17

PubMed score by year

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PubTator Score 70.53

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (8)

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PMID	Year	Title