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Tbio
PHF19
PHD finger protein 19

Protein Summary
Description
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312189
  • ENSP00000310372
  • ENSG00000119403
  • ENST00000373896
  • ENSP00000363003

Symbol
  • PCL3
  • PCL3
  • MTF2L1
  • TDRD19B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.88
microRNA
0.85
PubMedID
0.74
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.02   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.02   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
SUZ12
Tbio
Novelty:  0.00402353
p_int:  1
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
p_int:  0.999999896
p_ni:  1.02e-7
p_wrong:  3e-9
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
NRBP2
Tbio
Family:  Kinase
Novelty:  0.28776838
p_int:  0.999999428
p_ni:  5.14e-7
p_wrong:  5.8e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
EZH1
Tchem
Family:  Epigenetic
Novelty:  0.02636757
p_int:  0.999998633
p_ni:  0.000001349
p_wrong:  1.8e-8
Score:  0.941
Data Source:  BioPlex,STRINGDB
EED
Tchem
Novelty:  0.00615758
p_int:  0.999991034
p_ni:  0.000008966
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.999965841
p_ni:  0.000034159
Score:  0.183
Data Source:  BioPlex,STRINGDB
GTF2F1
Tbio
Novelty:  0.02118098
p_int:  0.999929818
p_ni:  0.000070182
Score:  0.233
Data Source:  BioPlex,STRINGDB
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
p_int:  0.999851308
p_ni:  0.000110507
p_wrong:  0.000038184
Score:  0.187
Data Source:  BioPlex,STRINGDB
CHAMP1
Tbio
Novelty:  0.09520274
p_int:  0.999561017
p_ni:  0.000438381
p_wrong:  6.02e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
PDLIM5
Tbio
Novelty:  0.0040646
p_int:  0.999555041
p_ni:  0.000444959
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Epigenetic regulation of gene expression (R-HSA-212165)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
PRC2 methylates histones and DNA
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
PRC2 methylates histones and DNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
2
1.1
93.1
birth weight
4
3
4
89.2
lymphocyte count
4
3
4
83
blood protein measurement
2
1
2
54.5
serum non-albumin protein measurement
1
1
1
54
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
93.1
birth weight
4
89.2
lymphocyte count
4
83
blood protein measurement
2
54.5
serum non-albumin protein measurement
1
54
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 19
704050
Mouse
MGI:1921266
74016
Rat
RGD:1310390
296653
Horse
PHD finger protein 19
VGNC:21378
100071777
Cow
PHD finger protein 19
VGNC:32817
532056
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 19
Mouse
Rat
Horse
PHD finger protein 19
Cow
PHD finger protein 19
Publication Statistics
PubMed Score 67.02
PubMed score by year
PubTator Score 70.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title