You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PHF10
PHD finger protein 10

Protein Summary
Description
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339209
  • ENSP00000341805
  • ENSG00000130024
  • ENST00000366780
  • ENSP00000355743
  • ENST00000621772
  • ENSP00000484117

Symbol
  • BAF45A
  • BAF45A
  • XAP135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor perturbation
0.88
histone modification site profile
0.85
ligand (protein) perturbation
0.83
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.99   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.99   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999998387
p_ni:  0.000001613
Data Source:  BioPlex
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.999993971
p_ni:  0.000006029
Data Source:  BioPlex
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999991171
p_ni:  0.000008829
Score:  0.983
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.999983278
p_ni:  0.000016722
Score:  0.979
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.99998318
p_ni:  0.00001682
Score:  0.991
Data Source:  BioPlex,STRINGDB
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999973537
p_ni:  0.000026463
Data Source:  BioPlex
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999964481
p_ni:  0.000035519
Score:  0.749
Data Source:  BioPlex,STRINGDB
DDX50
Tbio
Family:  Enzyme
Novelty:  0.05314506
p_int:  0.999806242
p_ni:  0.000193757
p_wrong:  1e-9
Data Source:  BioPlex
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999745475
p_ni:  0.000254525
Score:  0.528
Data Source:  BioPlex,STRINGDB
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.999737638
p_ni:  0.00026236
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
44.2
neutrophil count
1
1
1
40.7
smoking status measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
44.2
neutrophil count
1
40.7
smoking status measurement
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 10
VGNC:3615
463140
Macaque
PHD finger protein 10
695325
Mouse
MGI:1919307
72057
Rat
RGD:1305266
292404
Dog
PHD finger protein 10
VGNC:44480
475037
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 10
Macaque
PHD finger protein 10
Mouse
Rat
Dog
PHD finger protein 10
Publication Statistics
PubMed Score 18.99
PubMed score by year
PubTator Score 11.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title