Tbio PHF10 PHD finger protein 10

Protein Summary

Description

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WUB8
• Q2YDA3
• Q53HG8
• Q9BXD2
• Q9NV26

Gene Name

• PHF10

Ensembl ID

• ENST00000339209
• ENSP00000341805
• ENSG00000130024
• ENST00000366780
• ENSP00000355743
• ENST00000621772
• ENSP00000484117

Symbol

• BAF45A
• BAF45A
• XAP135

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
transcription factor perturbation	0.88
histone modification site profile	0.85
ligand (protein) perturbation	0.83
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Phd Finger Protein 10

Protein / Transcription Factor / Zinc Finger Transcription Factor / Phd Finger Protein 10

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Phd Finger Protein 10

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Phd Finger Protein 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0