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Tbio
PHB2
Prohibitin-2

Protein Summary
Description
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440277
  • ENSP00000412856
  • ENSG00000215021
  • ENST00000535923
  • ENSP00000441875

Symbol
  • BAP
  • REA
  • BAP
  • REA
  • p22
  • hBAP
  • Bap37
  • BCAP37
  • PNAS-141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
kinase perturbation
1
co-expressed gene
0.91
gene perturbation
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.26   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.26   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0