Protein Summary
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000300408
- ENSP00000300408
- ENSG00000167085
- ENST00000511832
- ENSP00000425035
- ENST00000614445
- ENSP00000479488
- ENST00000617874
- ENSP00000484113
- PHB1
- HEL-215
- HEL-S-54e
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
hub protein | 0.99 | ||
transcription factor perturbation | 0.97 | ||
biological process | 0.91 | ||
histone modification site profile | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 665.6 (req: < 5)
Gene RIFs: 128 (req: <= 3)
Antibodies: 649 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 665.6 (req: >= 5)
Gene RIFs: 128 (req: > 3)
Antibodies: 649 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0