Protein Summary
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000300408
- ENSP00000300408
- ENSG00000167085
- ENST00000511832
- ENSP00000425035
- ENST00000614445
- ENSP00000479488
- ENST00000617874
- ENSP00000484113
- PHB1
- HEL-215
- HEL-S-54e
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
hub protein | 0.99 | ||
transcription factor perturbation | 0.97 | ||
biological process | 0.91 | ||
histone modification site profile | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 602.67 (req: < 5)
Gene RIFs: 128 (req: <= 3)
Antibodies: 649 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 602.67 (req: >= 5)
Gene RIFs: 128 (req: > 3)
Antibodies: 649 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (200)
RIC3
Novelty: 0.0162412
p_int: 0.999632845
p_ni: 0.000367155
Score: 0.221
Data Source: BioPlex,STRINGDB
HIKESHI
Novelty: 0.0683189
p_int: 0.874658542
p_ni: 0.125336637
p_wrong: 0.000004821
Score: 0.301
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (20)
Reactome (19)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
FLT3 Signaling | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (8)
Components (18)
Processes (33)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 3 | 3 | 94.5 | |||||
7 | 5 | 0 | 1.1 | 90.3 | |||||
sex hormone-binding globulin measurement | 5 | 2 | 6 | 89.3 | |||||
4 | 4 | 4 | 86.2 | ||||||
eosinophil count | 3 | 2 | 3 | 85 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 94.5 | |||||
0 | 1.1 | 90.3 | |||||
sex hormone-binding globulin measurement | 6 | 89.3 | |||||
4 | 86.2 | ||||||
eosinophil count | 3 | 85 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | prohibitin | VGNC:9514 | 455205 | |||||
Macaque | prohibitin | 699334 | ||||||
Mouse | MGI:97572 | 18673 | ||||||
Rat | RGD:3322 | 25344 | ||||||
Dog | prohibitin | 480547 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | prohibitin | |||||
Macaque | prohibitin | |||||
Mouse | ||||||
Rat | ||||||
Dog | prohibitin | |||||
Publication Statistics
PubMed Score 602.67
PubMed score by year
PubTator Score 326.11
PubTator score by year
Related Publications
Text Mined References (187)
GeneRif Annotations (128)
Items per page:
0 of 0
PMID | Year | Title |
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