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Tbio
PHACTR4
Phosphatase and actin regulator 4

Protein Summary
Description
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373836
  • ENSP00000362942
  • ENSG00000204138
  • ENST00000373839
  • ENSP00000362945
  • ENST00000493669
  • ENSP00000488359

Symbol
  • PPP1R124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
virus perturbation
0.92
kinase perturbation
0.88
transcription factor binding site profile
0.82
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
IFIT2
Tbio
Novelty:  0.01023074
p_int:  1
Score:  0.825
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999999971
p_ni:  2.7e-8
p_wrong:  2e-9
Data Source:  BioPlex
IFIT3
Tbio
Novelty:  0.00568113
p_int:  0.999999932
p_ni:  6.6e-8
p_wrong:  2e-9
Score:  0.672
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999999931
p_ni:  6.6e-8
p_wrong:  3e-9
Data Source:  BioPlex
IFIT1
Tbio
Novelty:  0.00562299
p_int:  0.99999923
p_ni:  4.25e-7
p_wrong:  3.45e-7
Score:  0.691
Data Source:  BioPlex,STRINGDB
RAB9B
Tbio
Family:  Enzyme
Novelty:  0.19952686
p_int:  0.999971442
p_ni:  0.000028558
Score:  0.226
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999955288
p_ni:  0.000044712
Score:  0.394
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999943754
p_ni:  0.000056246
Score:  0.454
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.99947498
p_ni:  0.000524998
p_wrong:  2.3e-8
Data Source:  BioPlex
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.986170597
p_ni:  0.013829351
p_wrong:  5.2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
69.3
uric acid measurement
1
1
1
26.6
eosinophil count
2
1
2
17.7
eosinophil percentage of leukocytes
1
1
1
12.2
self reported educational attainment
1
1
1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
69.3
uric acid measurement
1
26.6
eosinophil count
2
17.7
eosinophil percentage of leukocytes
1
12.2
self reported educational attainment
1
10.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatase and actin regulator 4
716990
Mouse
MGI:2140327
100169
Rat
RGD:1592823
682920
Dog
phosphatase and actin regulator 4
VGNC:44475
487333
Horse
phosphatase and actin regulator 4
VGNC:21366
100070745
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatase and actin regulator 4
Mouse
Rat
Dog
phosphatase and actin regulator 4
Horse
phosphatase and actin regulator 4
Publication Statistics
PubMed Score 9.99
PubMed score by year
PubTator Score 4.25
PubTator score by year
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Related Publications
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PMID
Year
Title