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Tbio
PHACTR2
Phosphatase and actin regulator 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305766
  • ENSP00000305530
  • ENSG00000112419
  • ENST00000367582
  • ENSP00000356554
  • ENST00000427704
  • ENSP00000391763
  • ENST00000440869
  • ENSP00000417038

Symbol
  • C6orf56
  • KIAA0680
  • C6orf56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
trait
0.97
virus perturbation
0.88
ligand (protein) perturbation
0.83
microRNA
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.99999998
p_ni:  5e-9
p_wrong:  1.5e-8
Score:  0.558
Data Source:  BioPlex,STRINGDB
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.99999996
p_ni:  3.9e-8
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999999889
p_ni:  1.1e-7
Score:  0.439
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.999918548
p_ni:  0.000081452
Score:  0.719
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.99921304
p_ni:  0.00078696
Score:  0.45
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.998398609
p_ni:  0.001601391
Score:  0.703
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.991566929
p_ni:  0.008431476
p_wrong:  0.000001595
Score:  0.688
Data Source:  BioPlex,STRINGDB
ACTC1
Tbio
Novelty:  0.00188036
p_int:  0.989554855
p_ni:  0.010445145
Score:  0.887
Data Source:  BioPlex,STRINGDB
SLITRK6
Tbio
Novelty:  0.07618633
Score:  0.687
Data Source:  STRINGDB
RNF146
Tbio
Family:  Enzyme
Novelty:  0.05463359
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
1
2
65.8
multiple sclerosis
1
1
0
1.1
55
skin aging measurement
1
1
1
52.7
1
1
0
1.1
35.5
educational attainment
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
65.8
multiple sclerosis
0
1.1
55
skin aging measurement
1
52.7
0
1.1
35.5
educational attainment
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatase and actin regulator 2
VGNC:11163
463040
Macaque
phosphatase and actin regulator 2
700363
Mouse
MGI:2446138
215789
Rat
RGD:1303141
308291
Dog
phosphatase and actin regulator 2
VGNC:44473
476230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatase and actin regulator 2
Macaque
phosphatase and actin regulator 2
Mouse
Rat
Dog
phosphatase and actin regulator 2
Publication Statistics
PubMed Score 4.58
PubMed score by year
PubTator Score 2.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title