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Tclin
PGR
Progesterone receptor

Protein Summary
Description
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263463
  • ENSP00000263463
  • ENSG00000082175
  • ENST00000325455
  • ENSP00000325120
  • ENST00000534013
  • ENSP00000436561

Symbol
  • NR3C3
  • PR
  • NR3C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.99
biological term
0.97
disease
0.89
drug
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10765.01   (req: < 5)
Gene RIFs: 570   (req: <= 3)
Antibodies: 2677   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10765.01   (req: >= 5)
Gene RIFs: 570   (req: > 3)
Antibodies: 2677   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 951
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 25