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Tclin
PGR
Progesterone receptor

Protein Summary
Description
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263463
  • ENSP00000263463
  • ENSG00000082175
  • ENST00000325455
  • ENSP00000325120
  • ENST00000534013
  • ENSP00000436561

Symbol
  • NR3C3
  • PR
  • NR3C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.99
biological term
0.97
disease
0.89
drug
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10352.22   (req: < 5)
Gene RIFs: 570   (req: <= 3)
Antibodies: 2677   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10352.22   (req: >= 5)
Gene RIFs: 570   (req: > 3)
Antibodies: 2677   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 951
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 25
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (25)
progesterone
Rendered image for progesterone
fulvestrant
Rendered image for fulvestrant
medroxyprogesterone
Rendered image for medroxyprogesterone
danazol
Rendered image for danazol
mifepristone
Rendered image for mifepristone
budesonide
Rendered image for budesonide
fluticasone propionate
Rendered image for fluticasone propionate
mometasone furoate
Rendered image for mometasone furoate
norethindrone acetate
Rendered image for norethindrone acetate
norgestimate
Rendered image for norgestimate
Protein-Protein Interactions (299)
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.985
Data Source:  STRINGDB
FKBP4
Tchem
Family:  Enzyme
Novelty:  0.0023525
Score:  0.973
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.973
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.972
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.964
Data Source:  Reactome,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
Score:  0.963
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.961
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.96
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.957
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
9
48.5
menstrual cycle measurement
1
1
1
17.8
diastolic blood pressure
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
9
48.5
menstrual cycle measurement
1
17.8
diastolic blood pressure
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor
VGNC:11682
451502
Macaque
progesterone receptor
613024
Mouse
MGI:97567
18667
Rat
RGD:3317
25154
Dog
progesterone receptor
VGNC:44469
403621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor
Macaque
progesterone receptor
Mouse
Rat
Dog
progesterone receptor
Publication Statistics
PubMed Score 10352.22
PubMed score by year
PubTator Score 5940.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title