Tclin PGR Progesterone receptor

Protein Summary

Description

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P06401
• A7LQ08
• A7X8B0
• B4E3T0
• Q8TDS3
• Q9UPF7
• PR

Gene Name

• PGR

Ensembl ID

• ENST00000263463
• ENSP00000263463
• ENSG00000082175
• ENST00000325455
• ENSP00000325120
• ENST00000534013
• ENSP00000436561

Symbol

• NR3C3
• PR
• NR3C3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
molecular function	0.99
biological term	0.97
disease	0.89
drug	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Progesterone Receptor

Protein / Receptor / Progesterone Receptor

Protein / Nucleic Acid Binding / Progesterone Receptor

Protein / ... / C4 Zinc Finger Nuclear Receptor / Progesterone Receptor

DTO Classes

Protein / Nuclear Receptor / 3-ketosteroid Receptors / Progesterone Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10765.01   (req: < 5)

Gene RIFs: 644   (req: <= 3)

Antibodies: 2677   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10765.01   (req: >= 5)

Gene RIFs: 644   (req: > 3)

Antibodies: 2677   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 951

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 25