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Tbio
PGM3
Phosphoacetylglucosamine mutase

Protein Summary
Description
Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000506587
  • ENSP00000425809
  • ENSG00000013375
  • ENST00000512866
  • ENSP00000421565
  • ENST00000513973
  • ENSP00000424874

Symbol
  • AGM1
  • AGM1
  • PAGM
  • IMD23
  • PGM 3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
0.97
protein domain
0.85
microRNA
0.84
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (183)
UAP1
Tbio
Family:  Enzyme
Novelty:  0.02034314
Score:  0.991
Data Source:  STRINGDB
GNPNAT1
Tbio
Family:  Enzyme
Novelty:  0.01739665
Score:  0.988
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.981
Data Source:  STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
Score:  0.965
Data Source:  STRINGDB
PUDP
Tbio
Family:  Enzyme
Novelty:  0.11180277
Score:  0.945
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.902
Data Source:  STRINGDB
PGM5
Tbio
Family:  Enzyme
Novelty:  0.05352185
Score:  0.877
Data Source:  STRINGDB
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
Score:  0.874
Data Source:  STRINGDB
GLO1
Tchem
Family:  Enzyme
Novelty:  0.00225012
Score:  0.854
Data Source:  STRINGDB
GFPT1
Tchem
Family:  Enzyme
Novelty:  0.00358283
Score:  0.835
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
31.4
vitamin D measurement
1
1
1
26.6
platelet-derived growth factor BB measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
31.4
vitamin D measurement
1
26.6
platelet-derived growth factor BB measurement
1
2.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoglucomutase 3
VGNC:11148
462852
Macaque
phosphoglucomutase 3
694464
Mouse
MGI:97566
109785
Rat
RGD:1305221
363109
Dog
phosphoglucomutase 3
VGNC:44466
474981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoglucomutase 3
Macaque
phosphoglucomutase 3
Mouse
Rat
Dog
phosphoglucomutase 3
Publication Statistics
PubMed Score 201.99
PubMed score by year
PubTator Score 101.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title