Tbio PGLYRP1 Peptidoglycan recognition protein 1

Protein Summary

Description

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Uniprot Accession IDs

• O75594
• Q4VB36

Gene Name

• PGLYRP1

Ensembl ID

• ENST00000008938
• ENSP00000008938
• ENSG00000008438

Symbol

• PGLYRP
• PGRP
• TNFSF3L
• PGRP
• TAG7
• PGRPS
• PGLYRP
• PGRP-S
• TNFSF3L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.76
molecular function	0.76
disease perturbation	0.74
gene perturbation	0.67
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 614.95   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 343   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 614.95   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0