PGLYRP1
Peptidoglycan recognition protein 1
Protein Summary
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
- ENST00000008938
- ENSP00000008938
- ENSG00000008438
- PGLYRP
- PGRP
- TNFSF3L
- PGRP
- TAG7
- PGRPS
- PGLYRP
- PGRP-S
- TNFSF3L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.76 | ||
molecular function | 0.76 | ||
disease perturbation | 0.74 | ||
gene perturbation | 0.67 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 511.58 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 343 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 511.58 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 343 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (118)
IFNA2
Novelty: 0.00032935
p_int: 0.992465304
p_ni: 0.007251264
p_wrong: 0.000283432
Score: 0.53
Data Source: BioPlex,STRINGDB
CNRIP1
Novelty: 0.06888531
p_int: 0.89799899
p_ni: 0.101998752
p_wrong: 0.000002258
Score: 0.54
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (4)
Components (6)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 44 | |||||
apolipoprotein B measurement | 1 | 1 | 1 | 33.1 | |||||
electrocardiography | 1 | 1 | 1 | 21.5 | |||||
hematocrit | 1 | 1 | 1 | 5.9 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 44 | |||||
apolipoprotein B measurement | 1 | 33.1 | |||||
electrocardiography | 1 | 21.5 | |||||
hematocrit | 1 | 5.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | peptidoglycan recognition protein 1 | VGNC:2289 | 468926 | |||||
Macaque | peptidoglycan recognition protein 1 | 718480 | ||||||
Mouse | MGI:1345092 | 21946 | ||||||
Rat | RGD:621429 | 84387 | ||||||
Dog | peptidoglycan recognition protein 1 | VGNC:44461 | 612209 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | peptidoglycan recognition protein 1 | |||||
Macaque | peptidoglycan recognition protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | peptidoglycan recognition protein 1 | |||||
Publication Statistics
PubMed Score 511.58
PubMed score by year
PubTator Score 74.21
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
|---|