Protein Summary
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959). The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and ...more
- ENST00000373316
- ENSP00000362413
- ENSG00000102144
- ENST00000644362
- ENSP00000496140
- PGKA
- PGKA
- MIG10
- HEL-S-68p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
transcription factor perturbation | 1 | ||
interacting protein | 0.99 | ||
hub protein | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 815.66 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 438 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 815.66 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 438 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (8)
Protein-Protein Interactions (321)
PGK2
Family: Kinase
Novelty: 0.00832045
p_int: 0.999678996
p_ni: 0.000321004
Score: 0.853
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (22)
Reactome (5)
KEGG (5)
PathwayCommons (6)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gluconeogenesis | ||||
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gluconeogenesis | ||||
Glucose metabolism | ||||
Glycolysis | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (4)
Components (5)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 79.8 | |||||
mean platelet volume | 1 | 1 | 1 | 61 | |||||
potassium measurement | 1 | 1 | 1 | 8.7 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 79.8 | |||||
mean platelet volume | 1 | 61 | |||||
potassium measurement | 1 | 8.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphoglycerate kinase 1 | VGNC:1208 | 473678 | |||||
Macaque | phosphoglycerate kinase 1 | 706325 | ||||||
Mouse | MGI:97555 | 18655 | ||||||
Rat | RGD:619878 | 24644 | ||||||
Dog | phosphoglycerate kinase 1 | VGNC:49941 | 480964 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphoglycerate kinase 1 | |||||
Macaque | phosphoglycerate kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphoglycerate kinase 1 | |||||
Publication Statistics
PubMed Score 815.66
PubMed score by year
PubTator Score 226.18
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (101)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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