Tchem PGK1 Phosphoglycerate kinase 1

Protein Summary

Description

In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959). The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P00558
• A8K4W6
• B7Z7A9
• Q5J7W1
• Q6IBT6
• Q8NI87

Gene Name

• PGK1

Ensembl ID

• ENST00000373316
• ENSP00000362413
• ENSG00000102144
• ENST00000644362
• ENSP00000496140

Symbol

• PGKA
• PGKA
• MIG10
• HEL-S-68p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
transcription factor perturbation	1
interacting protein	0.99
hub protein	0.97

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Carbohydrate Kinase / Phosphoglycerate Kinase 1

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Phosphoglycerate Kinase Family / Phosphoglycerate Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 955.53   (req: < 5)

Gene RIFs: 88   (req: <= 3)

Antibodies: 438   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 955.53   (req: >= 5)

Gene RIFs: 88   (req: > 3)

Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0