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Tchem
PGGT1B
Geranylgeranyl transferase type-1 subunit beta

Protein Summary
Description
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379615
  • ENSP00000368935
  • ENSG00000164219
  • ENST00000419445
  • ENSP00000404676

Symbol
  • BGGI
  • GGTI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.71
molecular function
0.67
tissue sample
0.67
small molecule perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (68)
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
AMMECR1L
Tdark
Novelty:  0.60058793
p_int:  0.999999989
p_ni:  6e-9
p_wrong:  4e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
HEYL
Tbio
Family:  TF
Novelty:  0.00643194
p_int:  0.99999909
p_ni:  6.39e-7
p_wrong:  2.71e-7
Score:  0.534
Data Source:  BioPlex,STRINGDB
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.999998174
p_ni:  0.000001821
p_wrong:  5e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.9999958
p_ni:  0.000004197
p_wrong:  2e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
SRGAP3
Tbio
Family:  Enzyme
Novelty:  0.01913784
p_int:  0.999975827
p_ni:  0.000024115
p_wrong:  5.9e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.861
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.857
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.841
Data Source:  STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein geranylgeranyltransferase type I subunit beta
VGNC:7099
471600
Macaque
protein geranylgeranyltransferase type I subunit beta
696437
Mouse
MGI:1917514
225467
Rat
RGD:621754
81746
Dog
protein geranylgeranyltransferase type I subunit beta
VGNC:44459
481440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein geranylgeranyltransferase type I subunit beta
Macaque
protein geranylgeranyltransferase type I subunit beta
Mouse
Rat
Dog
protein geranylgeranyltransferase type I subunit beta
Publication Statistics
PubMed Score 13.36
PubMed score by year
PubTator Score 56.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title