You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PGF
Placenta growth factor

Protein Summary
Description
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405431
  • ENSP00000385365
  • ENSG00000119630
  • ENST00000553716
  • ENSP00000451413
  • ENST00000555567
  • ENSP00000451040

Symbol
  • PGFL
  • PLGF
  • PGFL
  • PIGF
  • PLGF
  • PlGF-2
  • D12S1900
  • SHGC-10760
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
PubMedID
0.69
disease
0.65
biological process
0.6
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2308.51   (req: < 5)
Gene RIFs: 297   (req: <= 3)
Antibodies: 860   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2308.51   (req: >= 5)
Gene RIFs: 297   (req: > 3)
Antibodies: 860   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1