Protein Summary
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
- ENST00000405431
- ENSP00000385365
- ENSG00000119630
- ENST00000553716
- ENSP00000451413
- ENST00000555567
- ENSP00000451040
- PGFL
- PLGF
- PGFL
- PIGF
- PLGF
- PlGF-2
- D12S1900
- SHGC-10760
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.97 | ||
PubMedID | 0.69 | ||
disease | 0.65 | ||
biological process | 0.6 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1995.71 (req: < 5)
Gene RIFs: 297 (req: <= 3)
Antibodies: 860 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1995.71 (req: >= 5)
Gene RIFs: 297 (req: > 3)
Antibodies: 860 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (16)
Protein-Protein Interactions (153)
Nearest Tclin Targets
Pathways (17)
Reactome (5)
KEGG (6)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Reactome | Signaling by VEGF | ||||
Reactome | VEGF binds to VEGFR leading to receptor dimerization | ||||
Reactome | VEGF ligand-receptor interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Signaling by VEGF | ||||
VEGF binds to VEGFR leading to receptor dimerization | ||||
VEGF ligand-receptor interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (6)
Components (3)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neuroticism measurement | 3 | 5 | 1 | 6.5 | 78.4 | ||||
worry measurement | 2 | 4 | 3 | 6 | 71.8 | ||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 63.1 | |||||
2 | 2 | 2 | 56.6 | ||||||
feeling nervous measurement | 1 | 1 | 0 | 6.9 | 53.3 | ||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neuroticism measurement | 1 | 6.5 | 78.4 | ||||
worry measurement | 3 | 6 | 71.8 | ||||
high density lipoprotein cholesterol measurement | 1 | 63.1 | |||||
2 | 56.6 | ||||||
feeling nervous measurement | 0 | 6.9 | 53.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | placental growth factor | VGNC:3348 | 741830 | |||||
Macaque | placental growth factor | 701219 | ||||||
Mouse | MGI:105095 | 18654 | ||||||
Rat | RGD:619850 | 94203 | ||||||
Dog | placental growth factor | VGNC:44457 | 100855780 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | placental growth factor | |||||
Macaque | placental growth factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | placental growth factor | |||||
Publication Statistics
PubMed Score 1995.71
PubMed score by year
PubTator Score 1605.97
PubTator score by year
Related Publications
Text Mined References (329)
GeneRif Annotations (297)
Items per page:
0 of 0
PMID | Year | Title |
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