You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
PGBD5
PiggyBac transposable element-derived protein 5

Protein Summary
Description
Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702). Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780). The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391860
  • ENSP00000375733
  • ENSG00000177614
  • ENST00000525115
  • ENSP00000431404
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.64
microRNA
0.55
tissue sample
0.54
kinase perturbation
0.48
small molecule perturbation
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999999991
p_ni:  1e-9
p_wrong:  8e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
THAP9
Tbio
Family:  TF
Novelty:  0.25915023
Score:  0.854
Data Source:  STRINGDB
HARBI1
Tdark
Family:  Enzyme
Novelty:  0.22704408
Score:  0.795
Data Source:  STRINGDB
QRICH1
Tdark
Novelty:  0.27714699
Score:  0.791
Data Source:  STRINGDB
EFCAB2
Tdark
Novelty:  0.26420728
Score:  0.77
Data Source:  STRINGDB
PGBD2
Tdark
Novelty:  2.01193283
Score:  0.762
Data Source:  STRINGDB
GIN1
Tbio
Family:  Enzyme
Novelty:  0.0247804
Score:  0.749
Data Source:  STRINGDB
ZBED8
Tdark
Novelty:  2.26997341
Score:  0.72
Data Source:  STRINGDB
SETMAR
Tbio
Family:  Epigenetic
Novelty:  0.02859547
Score:  0.717
Data Source:  STRINGDB
ZMYM3
Tbio
Novelty:  0.06911008
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (99)
Find Similar Targets
Items per page:
1 – 5 of 99
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Pathways in clear cell renal cell carcinoma
WikiPathways
Pathways in clear cell renal cell carcinoma
WikiPathways
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
WikiPathways
Signal Transduction of S1P Receptor
WikiPathways
IL-5 Signaling Pathway
Name
Explore in Pharos
Explore in Source
Pathways in clear cell renal cell carcinoma
Pathways in clear cell renal cell carcinoma
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
Signal Transduction of S1P Receptor
IL-5 Signaling Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
4
4
92.1
apolipoprotein A 1 measurement
2
4
4
87.2
triglyceride measurement
2
3
3
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
92.1
apolipoprotein A 1 measurement
4
87.2
triglyceride measurement
3
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piggyBac transposable element derived 5
VGNC:11611
101057280
Mouse
MGI:2429955
209966
Rat
RGD:1310825
292098
Dog
piggyBac transposable element derived 5
VGNC:44455
100855465
Horse
piggyBac transposable element derived 5
VGNC:21351
102149533
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piggyBac transposable element derived 5
Mouse
Rat
Dog
piggyBac transposable element derived 5
Horse
piggyBac transposable element derived 5
Publication Statistics
PubMed Score 10.69
PubMed score by year
PubTator Score 5.94
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title