Tbio PGAM4 Probable phosphoglycerate mutase 4

Protein Summary

Description

This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q8N0Y7
• Q5JPN2
• Q8NI24
• Q8NI25
• Q8NI26

Gene Name

• PGAM4

Ensembl ID

• ENST00000458128
• ENSP00000412189
• ENSG00000226784

Symbol

• PGAM3
• PGAM1
• PGAM3
• PGAM-B
• dJ1000K24.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.68
protein domain	0.58
cellular component	0.53
microRNA	0.49
tissue sample	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.09   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.09   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

PGAM2

Tbio

Family:  Enzyme

Novelty:  0.02438933

p_int:  0.999999999

p_wrong:  1e-9

Score:  0.935

Data Source:  BioPlex,STRINGDB

PGK1

Tchem

Family:  Kinase

Novelty:  0.00113494

Score:  0.987

Data Source:  STRINGDB

PGK2

Tbio

Family:  Kinase

Novelty:  0.00832045

Score:  0.977

Data Source:  STRINGDB

GPI

Tbio

Family:  Enzyme

Novelty:  0.00095404

Score:  0.952

Data Source:  STRINGDB

PHGDH

Tchem

Family:  Enzyme

Novelty:  0.00047542

Score:  0.931

Data Source:  STRINGDB

ENO1

Tchem

Family:  Enzyme

Novelty:  0.00109178

Score:  0.929

Data Source:  STRINGDB

TALDO1

Tbio

Family:  Enzyme

Novelty:  0.00208619

Score:  0.917

Data Source:  STRINGDB

TPI1

Tbio

Family:  Enzyme

Novelty:  0.00074652

Score:  0.915

Data Source:  STRINGDB

GLYCTK

Tbio

Family:  Kinase

Novelty:  0.06383854

Score:  0.91

Data Source:  STRINGDB

MINPP1

Tbio

Family:  Enzyme

Novelty:  0.02584444

Score:  0.906

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

KEGG (7)

Find Similar Targets

Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Central carbon metabolism in cancer	69 targets	path:hsa05230
KEGG	Glycolysis / Gluconeogenesis	68 targets	path:hsa00010
KEGG	Carbon metabolism	117 targets	path:hsa01200
KEGG	Glucagon signaling pathway	109 targets	path:hsa04922
KEGG	Glycine, serine and threonine metabolism	40 targets	path:hsa00260

Name	Explore in Pharos	Explore in Source
Central carbon metabolism in cancer	69 targets	path:hsa05230
Glycolysis / Gluconeogenesis	68 targets	path:hsa00010
Carbon metabolism	117 targets	path:hsa01200
Glucagon signaling pathway	109 targets	path:hsa04922
Glycine, serine and threonine metabolism	40 targets	path:hsa00260

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (3)

Components (2)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
phosphoglycerate mutase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
bisphosphoglycerate mutase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
hydrolase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		79.8
mean platelet volume	EFO_0004584	1	1	1		61

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		79.8
mean platelet volume	EFO_0004584	1		61

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Glycolysis
Hydrolase
Isomerase
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body height
mean platelet volume

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Xenopus	phosphoglycerate mutase 1	XB-GENE-1007742	100144939
Zebrafish	phosphoglycerate mutase 1a	ZDB-GENE-030131-1827	323107

Species	Name	OMA	EggNOG	Inparanoid
Xenopus	phosphoglycerate mutase 1
Zebrafish	phosphoglycerate mutase 1a

Publication Statistics

PubMed Score 25.09

PubMed score by year

Reset Zoom

PubTator Score 10.08

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title