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Tbio
PGAM2
Phosphoglycerate mutase 2

Protein Summary
Description
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297283
  • ENSP00000297283
  • ENSG00000164708

Symbol
  • PGAMM
  • GSD10
  • PGAMM
  • PGAM-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.75
protein domain
0.58
molecular function
0.56
cellular component
0.54
disease
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.14   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.14   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
PGAM4
Tbio
Family:  Enzyme
Novelty:  0.03784125
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.935
Data Source:  BioPlex,STRINGDB
BPGM
Tbio
Family:  Enzyme
Novelty:  0.03437401
p_int:  0.989874988
p_ni:  0.003858697
p_wrong:  0.006266315
Score:  0.954
Data Source:  BioPlex,STRINGDB
PGAM1
Tchem
Family:  Enzyme
Novelty:  0.0111272
p_int:  0.963309933
p_ni:  0.036690067
Score:  0.935
Data Source:  BioPlex,STRINGDB
PGK1
Tchem
Family:  Kinase
Novelty:  0.00113494
Score:  0.983
Data Source:  STRINGDB
ENO3
Tbio
Family:  Enzyme
Novelty:  0.00322051
Score:  0.983
Data Source:  STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
Score:  0.98
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.978
Data Source:  STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.964
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.95
Data Source:  STRINGDB
PHGDH
Tchem
Family:  Enzyme
Novelty:  0.00047542
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
89
triglyceride measurement
3
3
3
87.3
glucose measurement
1
1
1
79.7
sex hormone-binding globulin measurement
3
1
3
58.4
4
2
2
1.1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
89
triglyceride measurement
3
87.3
glucose measurement
1
79.7
sex hormone-binding globulin measurement
3
58.4
2
1.1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1933118
56012
Rat
RGD:3313
24959
Dog
phosphoglycerate mutase 2
VGNC:44451
475495
Horse
phosphoglycerate mutase 2
VGNC:21345
100051714
Cow
phosphoglycerate mutase 2
VGNC:32779
515067
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphoglycerate mutase 2
Horse
phosphoglycerate mutase 2
Cow
phosphoglycerate mutase 2
Publication Statistics
PubMed Score 44.14
PubMed score by year
PubTator Score 30.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title