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Tchem
PGAM1
Phosphoglycerate mutase 1

Protein Summary
Description
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334828
  • ENSP00000359991
  • ENSG00000171314

Symbol
  • PGAMA
  • PGAMA
  • PGAM-B
  • HEL-S-35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.88
transcription factor binding site profile
0.83
tissue
0.77
disease
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.06   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.06   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (103)
PGAM2
Tbio
Family:  Enzyme
Novelty:  0.02438933
p_int:  0.963309933
p_ni:  0.036690067
Score:  0.935
Data Source:  BioPlex,STRINGDB
ENO3
Tbio
Family:  Enzyme
Novelty:  0.00322051
Score:  0.994
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.993
Data Source:  STRINGDB
PGK1
Tchem
Family:  Kinase
Novelty:  0.00113494
Score:  0.99
Data Source:  STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.984
Data Source:  STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
Score:  0.978
Data Source:  STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.969
Data Source:  STRINGDB
PHGDH
Tchem
Family:  Enzyme
Novelty:  0.00047542
Score:  0.968
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.962
Data Source:  STRINGDB
G6PD
Tchem
Family:  Enzyme
Novelty:  0.00064455
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
3
3
95.9
monocyte percentage of leukocytes
2
2
2
90.7
serum gamma-glutamyl transferase measurement
1
1
1
42.3
granulocyte percentage of myeloid white cells
1
1
1
40.7
risk-taking behaviour
1
1
1
31.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
95.9
monocyte percentage of leukocytes
2
90.7
serum gamma-glutamyl transferase measurement
1
42.3
granulocyte percentage of myeloid white cells
1
40.7
risk-taking behaviour
1
31.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoglycerate mutase 1
VGNC:12419
450650
Macaque
phosphoglycerate mutase 1
706211
Mouse
MGI:97552
18648
Rat
RGD:3312
24642
Cow
phosphoglycerate mutase 1
404148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoglycerate mutase 1
Macaque
phosphoglycerate mutase 1
Mouse
Rat
Cow
phosphoglycerate mutase 1
Publication Statistics
PubMed Score 96.06
PubMed score by year
PubTator Score 52.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title