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Tbio
PGA4
Pepsin A-4

Protein Summary
Description
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378149
  • ENSP00000367391
  • ENSG00000229183
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.54
disease
0.48
cellular component
0.42
tissue
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
PGA3
Tbio
Family:  Enzyme
Novelty:  0.04971357
Score:  0.96
Data Source:  STRINGDB
SFTPB
Tbio
Novelty:  0.00163925
Score:  0.907
Data Source:  STRINGDB
SFTPC
Tbio
Novelty:  0.00154396
Score:  0.9
Data Source:  STRINGDB
PGA5
Tclin
Family:  Enzyme
Novelty:  0.00810507
Score:  0.862
Data Source:  STRINGDB
CTRB2
Tdark
Family:  Enzyme
Novelty:  0.20557479
Score:  0.71
Data Source:  STRINGDB
CTRB1
Tchem
Family:  Enzyme
Novelty:  0.01637745
Score:  0.67
Data Source:  STRINGDB
PRSS3P2
Tdark
Family:  Enzyme
Novelty:  0.00959404
Score:  0.662
Data Source:  STRINGDB
PRSS2
Tchem
Family:  Enzyme
Novelty:  0.00959404
Score:  0.662
Data Source:  STRINGDB
MS4A1
Tclin
Novelty:  0.00701134
Score:  0.637
Data Source:  STRINGDB
PRSS1
Tclin
Family:  Enzyme
Novelty:  0.00157396
Score:  0.595
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
1
1
37.7
1
1
0
1.1
34.5
blood protein measurement
1
1
1
9.4
phosphatidylcholine measurement
1
1
1
3.7
serum albumin measurement
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
37.7
0
1.1
34.5
blood protein measurement
1
9.4
phosphatidylcholine measurement
1
3.7
serum albumin measurement
1
3.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 20.52
PubMed score by year
PubTator Score 6.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title