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Tdark
PFN4
Profilin-4

Protein Summary
Description
Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313213
  • ENSP00000322170
  • ENSG00000176732
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
tissue sample
0.74
cell type or tissue
0.53
cellular component
0.53
tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
PFN3
Tdark
Novelty:  0.11291078
Score:  0.975
Data Source:  STRINGDB
PFN2
Tbio
Novelty:  0.00605366
Score:  0.941
Data Source:  STRINGDB
PFN1
Tbio
Novelty:  0.0048861
Score:  0.912
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.872
Data Source:  STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.872
Data Source:  STRINGDB
DIAPH2
Tbio
Novelty:  0.02008076
Score:  0.859
Data Source:  STRINGDB
DIAPH1
Tbio
Novelty:  0.0150259
Score:  0.859
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.842
Data Source:  STRINGDB
APBB1IP
Tbio
Novelty:  0.01684051
Score:  0.822
Data Source:  STRINGDB
VASP
Tbio
Novelty:  0.00041984
Score:  0.676
Data Source:  STRINGDB
Pathways (542)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Salmonella infection
KEGG
Regulation of actin cytoskeleton
KEGG
Rap1 signaling pathway
KEGG
Shigellosis
Name
Explore in Pharos
Explore in Source
Salmonella infection
Regulation of actin cytoskeleton
Rap1 signaling pathway
Shigellosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
3
96.6
appendicular lean mass
3
4
6
91.6
reticulocyte count
7
2
7
90.3
reticulocyte measurement
3
2
3
88.2
lymphocyte percentage of leukocytes
2
2
2
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
96.6
appendicular lean mass
6
91.6
reticulocyte count
7
90.3
reticulocyte measurement
3
88.2
lymphocyte percentage of leukocytes
2
77.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
profilin family member 4
VGNC:10737
100611207
Macaque
profilin family member 4
704416
Mouse
MGI:1920121
382562
Rat
RGD:1359707
494222
Dog
profilin family member 4
VGNC:44450
610829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
profilin family member 4
Macaque
profilin family member 4
Mouse
Rat
Dog
profilin family member 4
Publication Statistics
PubMed Score 3.29
PubMed score by year
PubTator Score 3.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title