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Tdark
PFN3
Profilin-3

Protein Summary
Description
Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. The product of this gene belongs to the profilin family of proteins. This protein binds to actin and affects the structure of the cytoskeleton. It also may be involved in spermatogenesis. It is a single exon gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358571
  • ENSP00000351379
  • ENSG00000196570
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.45
cellular component
0.42
cell type or tissue
0.41
protein domain
0.41
transcription factor
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
TCHHL1
Tdark
Novelty:  0.21799821
p_int:  0.999998996
p_ni:  3.94e-7
p_wrong:  6.11e-7
Data Source:  BioPlex
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.999895525
p_ni:  0.000104475
Score:  0.186
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999786377
p_ni:  0.000213623
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.999334591
p_ni:  0.000665409
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.998017255
p_ni:  0.001982745
Score:  0.837
Data Source:  BioPlex,STRINGDB
ACTC1
Tbio
Novelty:  0.00188036
p_int:  0.945822438
p_ni:  0.054177562
Score:  0.222
Data Source:  BioPlex,STRINGDB
GLRX
Tbio
Novelty:  0.00111903
p_int:  0.90385693
p_ni:  0.086043241
p_wrong:  0.010099829
Data Source:  BioPlex
PFN4
Tdark
Novelty:  0.2502443
Score:  0.975
Data Source:  STRINGDB
ACTRT3
Tdark
Novelty:  0.36920501
Score:  0.853
Data Source:  STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.827
Data Source:  STRINGDB
Pathways (61)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Salmonella infection
KEGG
Regulation of actin cytoskeleton
KEGG
Rap1 signaling pathway
KEGG
Shigellosis
Name
Explore in Pharos
Explore in Source
Salmonella infection
Regulation of actin cytoskeleton
Rap1 signaling pathway
Shigellosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
9
12
15.2
99.4
creatinine measurement
5
7
8
97.1
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
12
15.2
99.4
creatinine measurement
8
97.1
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2178800
75477
Rat
RGD:1587838
685936
Dog
profilin 3
VGNC:44449
489091
Horse
profilin 3
VGNC:21343
100146754
Cow
profilin 3
VGNC:32777
521379
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
profilin 3
Horse
profilin 3
Cow
profilin 3
Publication Statistics
PubMed Score 11.34
PubMed score by year
PubTator Score 3.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title