Protein Summary
Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. The product of this gene belongs to the profilin family of proteins. This protein binds to actin and affects the structure of the cytoskeleton. It also may be involved in spermatogenesis. It is a single exon gene. [provided by RefSeq, Jul 2008]
- ENST00000358571
- ENSP00000351379
- ENSG00000196570
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.45 | ||
cellular component | 0.42 | ||
cell type or tissue | 0.41 | ||
protein domain | 0.41 | ||
transcription factor | 0.38 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.34 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 20 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.34 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 20 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
TCHHL1
Novelty: 0.21799821
p_int: 0.999998996
p_ni: 3.94e-7
p_wrong: 6.11e-7
Data Source: BioPlex
ACTA2
Novelty: 0.00199354
p_int: 0.999895525
p_ni: 0.000104475
Score: 0.186
Data Source: BioPlex,STRINGDB
ACTB
Novelty: 0.00006048
p_int: 0.998017255
p_ni: 0.001982745
Score: 0.837
Data Source: BioPlex,STRINGDB
ACTC1
Novelty: 0.00188036
p_int: 0.945822438
p_ni: 0.054177562
Score: 0.222
Data Source: BioPlex,STRINGDB
GLRX
Novelty: 0.00111903
p_int: 0.90385693
p_ni: 0.086043241
p_wrong: 0.010099829
Data Source: BioPlex
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (61)
KEGG (4)
PathwayCommons (1)
WikiPathways (56)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Salmonella infection | ||||
KEGG | Regulation of actin cytoskeleton | ||||
KEGG | Rap1 signaling pathway | ||||
KEGG | Shigellosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Salmonella infection | ||||
Regulation of actin cytoskeleton | ||||
Rap1 signaling pathway | ||||
Shigellosis | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (57)
Items per page:
1 – 5 of 57
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 9 | 9 | 12 | 15.2 | 99.4 | ||||
creatinine measurement | 5 | 7 | 8 | 97.1 | |||||
partial thromboplastin time | 2 | 2 | 2 | 96.1 | |||||
hematocrit | 5 | 5 | 5 | 96.1 | |||||
hemoglobin measurement | 4 | 4 | 4 | 94.3 | |||||
Items per page:
1 – 5 of 57
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 12 | 15.2 | 99.4 | ||||
creatinine measurement | 8 | 97.1 | |||||
partial thromboplastin time | 2 | 96.1 | |||||
hematocrit | 5 | 96.1 | |||||
hemoglobin measurement | 4 | 94.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2178800 | 75477 | ||||||
Rat | RGD:1587838 | 685936 | ||||||
Dog | profilin 3 | VGNC:44449 | 489091 | |||||
Horse | profilin 3 | VGNC:21343 | 100146754 | |||||
Cow | profilin 3 | VGNC:32777 | 521379 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | profilin 3 | |||||
Horse | profilin 3 | |||||
Cow | profilin 3 | |||||
Publication Statistics
PubMed Score 11.34
PubMed score by year
PubTator Score 3.82
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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