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Tbio
PFN2
Profilin-2

Protein Summary
Description
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239940
  • ENSP00000239940
  • ENSG00000070087
  • ENST00000452853
  • ENSP00000410464

Symbol
  • PFL
  • D3S1319E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
gene perturbation
0.96
virus perturbation
0.92
molecular function
0.86
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.61   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.61   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
NAA80
Tbio
Family:  Enzyme
Novelty:  0.76363636
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
INF2
Tbio
Novelty:  0.00978892
p_int:  0.999999885
p_ni:  1.15e-7
Score:  0.793
Data Source:  BioPlex,STRINGDB
PALLD
Tbio
Novelty:  0.01191944
p_int:  0.999953612
p_ni:  0.000046387
p_wrong:  1e-9
Score:  0.344
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.998884943
p_ni:  0.001115057
Score:  0.442
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.997230494
p_ni:  0.002769506
Score:  0.451
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.99536493
p_ni:  0.00463507
Score:  0.979
Data Source:  BioPlex,STRINGDB
DIAPH1
Tbio
Novelty:  0.0150259
p_int:  0.992734706
p_ni:  0.007265294
p_wrong:  1e-9
Score:  0.943
Data Source:  BioPlex,STRINGDB
BLVRB
Tbio
Family:  Enzyme
Novelty:  0.00705559
p_int:  0.94932726
p_ni:  0.048557553
p_wrong:  0.002115187
Score:  0.204
Data Source:  BioPlex,STRINGDB
ENAH
Tbio
Novelty:  0.02329247
p_int:  0.91917266
p_ni:  0.08082734
Score:  0.986
Data Source:  BioPlex,STRINGDB
VASP
Tbio
Novelty:  0.00041984
p_int:  0.863762057
p_ni:  0.136237943
Score:  0.992
Data Source:  BioPlex,STRINGDB
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
RHO GTPase Effectors
RHO GTPases Activate Formins
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
50.6
neutrophil count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
50.6
neutrophil count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
profilin 2
VGNC:12124
460989
Macaque
profilin 2
713460
Mouse
MGI:97550
18645
Rat
Dog
profilin 2
VGNC:49940
100683352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
profilin 2
Macaque
profilin 2
Mouse
Rat
Dog
profilin 2
Publication Statistics
PubMed Score 168.61
PubMed score by year
PubTator Score 160.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title