You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PFKP
ATP-dependent 6-phosphofructokinase, platelet type

Protein Summary
Description
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381075
  • ENSP00000370465
  • ENSG00000067057
  • ENST00000381125
  • ENSP00000370517

Symbol
  • PFKF
  • PFKF
  • PFK-C
  • PFK-P
  • ATP-PFK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
transcription factor perturbation
1
PubMedID
0.99
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.99   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 431   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.99   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 431   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
NELL1
Tbio
Family:  Enzyme
Novelty:  0.01325888
p_int:  0.999753531
p_ni:  0.000246469
Score:  0.187
Data Source:  BioPlex,STRINGDB
PFKL
Tbio
Family:  Kinase
Novelty:  0.00586306
p_int:  0.99900033
p_ni:  0.00099967
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
PFKM
Tbio
Family:  Kinase
Novelty:  0.00217816
p_int:  0.888559613
p_ni:  0.111440385
p_wrong:  2e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.991
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.979
Data Source:  STRINGDB
ALDOC
Tbio
Family:  Enzyme
Novelty:  0.01552954
Score:  0.978
Data Source:  STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
Score:  0.975
Data Source:  STRINGDB
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
Score:  0.961
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (24)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
75.6
hematocrit
2
2
2
45.1
airway imaging measurement
1
1
1
40.7
HbA1c measurement
1
1
1
31.4
hemoglobin measurement
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
75.6
hematocrit
2
45.1
airway imaging measurement
1
40.7
HbA1c measurement
1
31.4
hemoglobin measurement
1
2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphofructokinase, platelet
VGNC:5624
450266
Macaque
phosphofructokinase, platelet
722330
Mouse
MGI:1891833
56421
Rat
RGD:61893
60416
Dog
phosphofructokinase, platelet
VGNC:44448
478019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphofructokinase, platelet
Macaque
phosphofructokinase, platelet
Mouse
Rat
Dog
phosphofructokinase, platelet
Publication Statistics
PubMed Score 121.99
PubMed score by year
PubTator Score 28.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title