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Tbio
PFKM
ATP-dependent 6-phosphofructokinase, muscle type

Protein Summary
Description
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312352
  • ENSP00000309438
  • ENSG00000152556
  • ENST00000340802
  • ENSP00000345771
  • ENST00000359794
  • ENSP00000352842
  • ENST00000547587
  • ENSP00000449426
  • ENST00000550345
  • ENSP00000450369
  • ENST00000550924
  • ENSP00000446945
  • ENST00000551339
  • ENSP00000448253
  • ENST00000551804
  • ENSP00000448177

Symbol
  • PFKX
  • GSD7
  • PFK1
  • PFKA
  • PFKX
  • PFK-1
  • PFK-A
  • ATP-PFK
  • PPP1R122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.99
disease perturbation
0.98
hub protein
0.98
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.77   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.77   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
PFKP
Tbio
Family:  Kinase
Novelty:  0.00808684
p_int:  0.888559613
p_ni:  0.111440385
p_wrong:  2e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
PFKL
Tbio
Family:  Kinase
Novelty:  0.00586306
Score:  0.994
Data Source:  Reactome,STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.993
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.976
Data Source:  STRINGDB
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
Score:  0.973
Data Source:  STRINGDB
ALDOC
Tbio
Family:  Enzyme
Novelty:  0.01552954
Score:  0.971
Data Source:  STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
Score:  0.97
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.962
Data Source:  STRINGDB
PFKFB3
Tchem
Family:  Kinase
Novelty:  0.00333471
Score:  0.955
Data Source:  STRINGDB
Pathways (25)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
4
5
97.4
HbA1c measurement
4
9
9
97.3
hematocrit
3
3
5
96
red blood cell density measurement
1
1
1
83.1
mean corpuscular volume
1
1
1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
5
97.4
HbA1c measurement
9
97.3
hematocrit
5
96
red blood cell density measurement
1
83.1
mean corpuscular volume
1
73.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphofructokinase, muscle
VGNC:13336
451863
Macaque
phosphofructokinase, muscle
707806
Mouse
MGI:97548
18642
Rat
RGD:68419
65152
Dog
phosphofructokinase, muscle
VGNC:44447
403849
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphofructokinase, muscle
Macaque
phosphofructokinase, muscle
Mouse
Rat
Dog
phosphofructokinase, muscle
Publication Statistics
PubMed Score 468.77
PubMed score by year
PubTator Score 131.87
PubTator score by year
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Related Publications
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PMID
Year
Title