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Tchem
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Protein Summary
Description
Synthesis and degradation of fructose 2,6-bisphosphate. The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360521
  • ENSP00000353712
  • ENSG00000170525
  • ENST00000379775
  • ENSP00000369100
  • ENST00000379789
  • ENSP00000369115
  • ENST00000536985
  • ENSP00000443319

Symbol
  • PFK2
  • IPFK2
  • iPFK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.91
protein domain
0.85
transcription factor
0.84
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.26   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.26   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (21)
CHEMBL3422677
Rendered image for CHEMBL3422677
CHEMBL3422678
Rendered image for CHEMBL3422678
PFK15
Rendered image for PFK15
PFKFB3 kinase Inhibitor 69
Rendered image for PFKFB3 kinase Inhibitor 69
CHEMBL4541928
Rendered image for CHEMBL4541928
CHEMBL4592338
Rendered image for CHEMBL4592338
CHEMBL3422674
Rendered image for CHEMBL3422674
CHEMBL4439789
Rendered image for CHEMBL4439789
CHEMBL3422676
Rendered image for CHEMBL3422676
CHEMBL4465124
Rendered image for CHEMBL4465124
Protein-Protein Interactions (101)
PFKFB4
Tchem
Family:  Enzyme
Novelty:  0.02847966
p_int:  1
Score:  0.968
Data Source:  BioPlex,STRINGDB
PFKFB2
Tchem
Family:  Kinase
Novelty:  0.01603779
p_int:  1
Score:  0.968
Data Source:  BioPlex,STRINGDB
PES1
Tbio
Novelty:  0.07162845
p_int:  0.999977139
p_ni:  0.000011736
p_wrong:  0.000011125
Score:  0.169
Data Source:  BioPlex,STRINGDB
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.933091302
p_ni:  0.066908698
Score:  0.223
Data Source:  BioPlex,STRINGDB
TIGAR
Tbio
Family:  Enzyme
Novelty:  0.0090389
Score:  0.973
Data Source:  STRINGDB
PFKM
Tbio
Family:  Kinase
Novelty:  0.00217816
Score:  0.955
Data Source:  STRINGDB
PFKFB1
Tbio
Family:  Kinase
Novelty:  0.03400219
Score:  0.928
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.916
Data Source:  STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
Score:  0.895
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.892
Data Source:  STRINGDB
Pathways (218)
Glucose metabolism (R-HSA-70326)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
8
8
0
1.2
99.6
type 1 diabetes mellitus
5
6
1
1.6
99.1
blood protein measurement
22
8
22
97.1
lymphocyte count
18
8
20
96.8
asthma
8
3
1
1.2
96
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.2
99.6
type 1 diabetes mellitus
1
1.6
99.1
blood protein measurement
22
97.1
lymphocyte count
20
96.8
asthma
1
1.2
96
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
VGNC:9756
738397
Macaque
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
713062
Mouse
MGI:2181202
170768
Rat
RGD:619776
117276
Dog
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
VGNC:44444
487139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Macaque
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Mouse
Rat
Dog
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Publication Statistics
PubMed Score 417.26
PubMed score by year
PubTator Score 155.76
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title