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Tbio
PFDN5
Prefoldin subunit 5

Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243040
  • ENSP00000243040
  • ENSG00000123349
  • ENST00000334478
  • ENSP00000334188
  • ENST00000351500
  • ENSP00000266964
  • ENST00000551018
  • ENSP00000447942

Symbol
  • MM1
  • PFD5
  • MM1
  • MM-1
  • PFD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.97
kinase perturbation
0.95
virus perturbation
0.88
phenotype
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (287)
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999920558
p_ni:  0.000079442
Score:  0.999
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.999801116
p_ni:  0.000198884
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.996168697
p_ni:  0.003831303
Score:  0.512
Data Source:  BioPlex,STRINGDB
VBP1
Tbio
Novelty:  0.0428293
p_int:  0.986330474
p_ni:  0.013669526
Score:  0.999
Data Source:  BioPlex,STRINGDB
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.869911825
p_ni:  0.130088175
Score:  0.54
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.863163528
p_ni:  0.136836472
Score:  0.741
Data Source:  BioPlex,STRINGDB
PFDN1
Tbio
Novelty:  0.08811378
Score:  0.999
Data Source:  STRINGDB
PFDN6
Tbio
Novelty:  0.01632101
Score:  0.999
Data Source:  STRINGDB
CCT8
Tbio
Novelty:  0.03168289
Score:  0.981
Data Source:  STRINGDB
CCT4
Tbio
Novelty:  0.01176123
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
4
3
5
95.2
mean corpuscular volume
3
3
3
86.3
alkaline phosphatase measurement
2
1
1
8.8
83.8
heel bone mineral density
2
2
2
82.7
body height
1
1
1
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
5
95.2
mean corpuscular volume
3
86.3
alkaline phosphatase measurement
1
8.8
83.8
heel bone mineral density
2
82.7
body height
1
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 5
VGNC:5530
451938
Macaque
prefoldin subunit 5
702355
Mouse
MGI:1928753
56612
Rat
RGD:1311436
300257
Dog
prefoldin subunit 5
607260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 5
Macaque
prefoldin subunit 5
Mouse
Rat
Dog
prefoldin subunit 5
Publication Statistics
PubMed Score 18.31
PubMed score by year
PubTator Score 108.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title