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Tbio
PFDN4
Prefoldin subunit 4

Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371419
  • ENSP00000360473
  • ENSG00000101132

Symbol
  • PFD4
  • C1
  • PFD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
transcription factor binding site profile
0.78
transcription factor perturbation
0.74
PubMedID
0.72
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
p_int:  0.999999605
p_ni:  1.29e-7
p_wrong:  2.66e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
VBP1
Tbio
Novelty:  0.0428293
p_int:  0.999999118
p_ni:  8.82e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.999995941
p_ni:  0.000004059
Score:  0.999
Data Source:  BioPlex,STRINGDB
KATNB1
Tbio
Novelty:  0.08472625
p_int:  0.999991821
p_ni:  0.000008179
Score:  0.554
Data Source:  BioPlex,STRINGDB
PFDN5
Tbio
Novelty:  0.07673574
p_int:  0.999920558
p_ni:  0.000079442
Score:  0.999
Data Source:  BioPlex,STRINGDB
PFDN1
Tbio
Novelty:  0.08811378
p_int:  0.999879815
p_ni:  0.000120185
Score:  0.999
Data Source:  BioPlex,STRINGDB
RC3H2
Tbio
Novelty:  0.10893793
p_int:  0.999849062
p_ni:  0.000085928
p_wrong:  0.00006501
Score:  0.233
Data Source:  BioPlex,STRINGDB
KATNA1
Tbio
Family:  Enzyme
Novelty:  0.05656063
p_int:  0.99966499
p_ni:  0.00033501
Score:  0.259
Data Source:  BioPlex,STRINGDB
PFDN6
Tbio
Novelty:  0.01632101
p_int:  0.999605185
p_ni:  0.000394815
Score:  0.999
Data Source:  BioPlex,STRINGDB
SPIN2B
Tchem
Novelty:  0.23202718
p_int:  0.999569589
p_ni:  0.00042492
p_wrong:  0.000005491
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
9
8
17
98.4
glomerular filtration rate
7
5
8
8.5
96.9
calcium measurement
2
6
5
10.9
95.2
creatinine measurement
4
5
6
86.3
3
3
0
1.1
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
17
98.4
glomerular filtration rate
8
8.5
96.9
calcium measurement
5
10.9
95.2
creatinine measurement
6
86.3
0
1.1
83.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 4
VGNC:14277
458346
Macaque
prefoldin subunit 4
698809
Mouse
MGI:1923512
109054
Rat
RGD:2324021
100366237
Horse
prefoldin subunit 4
VGNC:21334
100053649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 4
Macaque
prefoldin subunit 4
Mouse
Rat
Horse
prefoldin subunit 4
Publication Statistics
PubMed Score 34.04
PubMed score by year
PubTator Score 8.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title