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Tbio
PFAS
Phosphoribosylformylglycinamidine synthase

Protein Summary
Description
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314666
  • ENSP00000313490
  • ENSG00000178921

Symbol
  • KIAA0361
  • PURL
  • FGAMS
  • GATD8
  • FGARAT
  • FGAR-AT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
kinase perturbation
0.84
hub protein
0.75
microRNA
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
GART
Tclin
Novelty:  0.00524985
Score:  0.999
Data Source:  STRINGDB
PPAT
Tclin
Family:  Enzyme
Novelty:  0.01549862
Score:  0.994
Data Source:  STRINGDB
PAICS
Tchem
Novelty:  0.00215277
Score:  0.976
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.974
Data Source:  STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.963
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.942
Data Source:  STRINGDB
REEP5
Tbio
Novelty:  0.00160455
Score:  0.922
Data Source:  STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
Score:  0.899
Data Source:  STRINGDB
MTHFD1L
Tbio
Family:  Enzyme
Novelty:  0.01548353
Score:  0.898
Data Source:  STRINGDB
MTHFD1
Tchem
Family:  Enzyme
Novelty:  0.0071938
Score:  0.885
Data Source:  STRINGDB
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
1
1.1
92
total cholesterol measurement
2
2
2
87.7
mean corpuscular hemoglobin concentration
5
4
5
87.3
hematocrit
4
3
5
85.9
hemoglobin measurement
2
2
2
75.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
92
total cholesterol measurement
2
87.7
mean corpuscular hemoglobin concentration
5
87.3
hematocrit
5
85.9
hemoglobin measurement
2
75.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoribosylformylglycinamidine synthase
VGNC:9510
455093
Macaque
phosphoribosylformylglycinamidine synthase
717046
Mouse
MGI:2684864
237823
Rat
RGD:1304926
287420
Dog
phosphoribosylformylglycinamidine synthase
VGNC:44439
489490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoribosylformylglycinamidine synthase
Macaque
phosphoribosylformylglycinamidine synthase
Mouse
Rat
Dog
phosphoribosylformylglycinamidine synthase
Publication Statistics
PubMed Score 488.19
PubMed score by year
PubTator Score 88.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title