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Tbio
PF4
Platelet factor 4

Protein Summary
Description
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296029
  • ENSP00000296029
  • ENSG00000163737

Symbol
  • CXCL4
  • SCYB4
  • PF-4
  • CXCL4
  • SCYB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.93
gene perturbation
0.84
molecular function
0.6
disease
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3449.24   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3449.24   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (376)
BLZF1
Tbio
Novelty:  0.04344183
p_int:  0.999975835
p_ni:  0.000024165
Data Source:  BioPlex
MOCS1
Tclin
Novelty:  0.02785369
p_int:  0.997816173
p_ni:  0.002183779
p_wrong:  4.8e-8
Data Source:  BioPlex
CCL5
Tchem
Novelty:  0.00032607
Score:  0.99
Data Source:  STRINGDB
CXCR3
Tchem
Family:  GPCR
Novelty:  0.00100538
Score:  0.984
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.983
Data Source:  STRINGDB
PPBP
Tbio
Novelty:  0.00048307
Score:  0.98
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.979
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.978
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.977
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (27)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CXCL5 measurement
3
2
3
95.7
blood protein measurement
79
6
80
94.6
growth-regulated alpha protein measurement
2
2
1
1.2
84
neutrophil count
2
2
2
78.7
serum metabolite measurement
2
1
2
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CXCL5 measurement
3
95.7
blood protein measurement
80
94.6
growth-regulated alpha protein measurement
1
1.2
84
neutrophil count
2
78.7
serum metabolite measurement
2
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet factor 4
VGNC:658
740477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet factor 4
Publication Statistics
PubMed Score 3449.24
PubMed score by year
PubTator Score 1202.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title