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Tbio
PEX6
Peroxisome assembly factor 2

Protein Summary
Description
Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244546
  • ENSP00000244546
  • ENSG00000124587
  • ENST00000304611
  • ENSP00000303511

Symbol
  • PXAAA1
  • PAF2
  • HMLR2
  • PAF-2
  • PBD4A
  • PDB4B
  • PXAAA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
disease perturbation
0.93
histone modification site profile
0.65
transcription factor binding site profile
0.64
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.09   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.09   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.999958817
p_ni:  0.000041183
Data Source:  BioPlex
OVGP1
Tbio
Family:  Enzyme
Novelty:  0.00615902
p_int:  0.999947941
p_ni:  0.000052056
p_wrong:  2e-9
Data Source:  BioPlex
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.999568211
p_ni:  0.000431619
p_wrong:  1.7e-7
Data Source:  BioPlex
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999479332
p_ni:  0.000520668
Score:  0.265
Data Source:  BioPlex,STRINGDB
ENSA
Tbio
Novelty:  0.01642444
p_int:  0.999110736
p_ni:  0.00088904
p_wrong:  2.23e-7
Score:  0.182
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.998538973
p_ni:  0.001460816
p_wrong:  2.11e-7
Data Source:  BioPlex
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.997835226
p_ni:  0.002128291
p_wrong:  0.000036482
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.997747598
p_ni:  0.002252129
p_wrong:  2.73e-7
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.996214119
p_ni:  0.003467642
p_wrong:  0.000318239
Data Source:  BioPlex
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.991362644
p_ni:  0.006631123
p_wrong:  0.002006233
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Peroxisomal protein import (R-HSA-9033241)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
3
3
92.7
apolipoprotein B measurement
2
3
3
86.8
high density lipoprotein cholesterol measurement
3
3
4
83.6
bilirubin measurement
1
1
1
67.3
homocysteine measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
92.7
apolipoprotein B measurement
3
86.8
high density lipoprotein cholesterol measurement
4
83.6
bilirubin measurement
1
67.3
homocysteine measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 6
VGNC:3610
462704
Macaque
peroxisomal biogenesis factor 6
697597
Mouse
MGI:2385054
224824
Rat
RGD:621637
117265
Dog
peroxisomal biogenesis factor 6
VGNC:44437
481805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 6
Macaque
peroxisomal biogenesis factor 6
Mouse
Rat
Dog
peroxisomal biogenesis factor 6
Publication Statistics
PubMed Score 123.09
PubMed score by year
PubTator Score 47.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title