You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PEX5L
PEX5-related protein

Protein Summary
Description
Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263962
  • ENSP00000263962
  • ENSG00000114757
  • ENST00000392649
  • ENSP00000376420
  • ENST00000464614
  • ENSP00000417270
  • ENST00000465751
  • ENSP00000419348
  • ENST00000467460
  • ENSP00000419975
  • ENST00000468741
  • ENSP00000418665
  • ENST00000472994
  • ENSP00000418054
  • ENST00000476138
  • ENSP00000420555
  • ENST00000485199
  • ENSP00000418440

Symbol
  • PEX5R
  • PXR2
  • PXR2
  • PEX5R
  • PXR2B
  • PEX5RP
  • TRIP8b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
protein domain
0.85
virus perturbation
0.72
cell line
0.64
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.21   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.21   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
PEX7
Tbio
Novelty:  0.01487923
Score:  0.993
Data Source:  STRINGDB
PEX14
Tbio
Novelty:  0.0210557
Score:  0.987
Data Source:  STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.914
Data Source:  STRINGDB
SCP2
Tchem
Novelty:  0.00183736
Score:  0.908
Data Source:  STRINGDB
PEX3
Tbio
Novelty:  0.01171119
Score:  0.906
Data Source:  STRINGDB
PEX12
Tbio
Novelty:  0.02252744
Score:  0.886
Data Source:  STRINGDB
PEX16
Tbio
Novelty:  0.03119723
Score:  0.863
Data Source:  STRINGDB
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
Score:  0.845
Data Source:  STRINGDB
PEX10
Tbio
Novelty:  0.0174463
Score:  0.839
Data Source:  STRINGDB
PEX5
Tbio
Novelty:  0.00560901
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
60.7
biological sex
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
60.7
biological sex
1
45.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 5 like
VGNC:12123
471010
Macaque
peroxisomal biogenesis factor 5 like
708506
Mouse
MGI:1916672
58869
Rat
RGD:708407
286937
Dog
peroxisomal biogenesis factor 5 like
VGNC:44436
488088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 5 like
Macaque
peroxisomal biogenesis factor 5 like
Mouse
Rat
Dog
peroxisomal biogenesis factor 5 like
Publication Statistics
PubMed Score 74.21
PubMed score by year
PubTator Score 24.29
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title