PEX26
Peroxisome assembly protein 26
Protein Summary
Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical ...more
- ENST00000329627
- ENSP00000331106
- ENSG00000215193
- ENST00000399744
- ENSP00000382648
- ENST00000428061
- ENSP00000412441
- ENST00000610387
- ENSP00000482091
- PBD7A
- PBD7B
- PEX26M1T
- Pex26pM1T
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.85 | ||
transcription factor binding site profile | 0.77 | ||
phenotype | 0.75 | ||
tissue sample | 0.75 | ||
small molecule perturbation | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.43 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 121 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.43 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 121 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class I peroxisomal membrane protein import | ||||
Reactome | Peroxisomal protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class I peroxisomal membrane protein import | ||||
Peroxisomal protein import | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 87.3 | |||||
2 | 2 | 0 | 1.1 | 66.6 | |||||
lymphocyte count | 1 | 1 | 1 | 45.7 | |||||
1 | 1 | 0 | 1.1 | 39.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 1 | 87.3 | |||||
0 | 1.1 | 66.6 | |||||
lymphocyte count | 1 | 45.7 | |||||
0 | 1.1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1921293 | 74043 | ||||||
Rat | RGD:1584998 | 297570 | ||||||
Dog | peroxisomal biogenesis factor 26 | VGNC:44433 | 477743 | |||||
Horse | peroxisomal biogenesis factor 26 | VGNC:21327 | 100054664 | |||||
Cow | peroxisomal biogenesis factor 26 | VGNC:32759 | 537878 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | peroxisomal biogenesis factor 26 | |||||
Horse | peroxisomal biogenesis factor 26 | |||||
Cow | peroxisomal biogenesis factor 26 | |||||
Publication Statistics
PubMed Score 23.43
PubMed score by year
PubTator Score 10.63
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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