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Tbio
PEX2
Peroxisome biogenesis factor 2

Protein Summary
Description
Somewhat implicated in the biogenesis of peroxisomes. This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357039
  • ENSP00000349543
  • ENSG00000164751
  • ENST00000520103
  • ENSP00000428590
  • ENST00000522527
  • ENSP00000428638

Symbol
  • PAF1
  • PMP3
  • PMP35
  • PXMP3
  • RNF72
  • PAF1
  • PMP3
  • ZWS3
  • PBD5A
  • PBD5B
  • PMP35
  • PXMP3
  • RNF72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
kinase perturbation
0.88
transcription factor binding site profile
0.86
transcription factor perturbation
0.8
cellular component
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.83   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.83   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
PEX10
Tbio
Novelty:  0.0174463
Score:  0.999
Data Source:  Reactome,STRINGDB
PEX12
Tbio
Novelty:  0.02252744
Score:  0.998
Data Source:  Reactome,STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.996
Data Source:  Reactome,STRINGDB
PEX7
Tbio
Novelty:  0.01487923
Score:  0.995
Data Source:  Reactome,STRINGDB
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
Score:  0.993
Data Source:  Reactome,STRINGDB
PEX14
Tbio
Novelty:  0.0210557
Score:  0.991
Data Source:  Reactome,STRINGDB
PEX1
Tbio
Family:  Enzyme
Novelty:  0.08400632
Score:  0.988
Data Source:  Reactome,STRINGDB
PEX26
Tbio
Novelty:  0.04606868
Score:  0.975
Data Source:  Reactome,STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
Score:  0.971
Data Source:  STRINGDB
PEX5
Tbio
Novelty:  0.00560901
Score:  0.962
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Peroxisomal protein import
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Peroxisomal protein import
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 2
VGNC:13204
464242
Mouse
MGI:107486
19302
Rat
RGD:61814
29534
Dog
peroxisomal biogenesis factor 2
VGNC:54117
487007
Horse
peroxisomal biogenesis factor 2
100059654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 2
Mouse
Rat
Dog
peroxisomal biogenesis factor 2
Horse
peroxisomal biogenesis factor 2
Publication Statistics
PubMed Score 95.83
PubMed score by year
PubTator Score 38.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title