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Tbio
PEX16
Peroxisomal membrane protein PEX16

Protein Summary
Description
Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241041
  • ENSP00000241041
  • ENSG00000121680
  • ENST00000378750
  • ENSP00000368024

Symbol
  • PBD8A
  • PBD8B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.76
cellular component
0.74
disease perturbation
0.74
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.997510162
p_ni:  0.001804541
p_wrong:  0.000685297
Score:  0.958
Data Source:  BioPlex,Reactome,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.993664934
p_ni:  0.006334883
p_wrong:  1.83e-7
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.99065033
p_ni:  0.008848473
p_wrong:  0.000501197
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.980423148
p_ni:  0.018286217
p_wrong:  0.001290634
Data Source:  BioPlex
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.973921623
p_ni:  0.025779358
p_wrong:  0.000299019
Data Source:  BioPlex
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.973921623
p_ni:  0.025779358
p_wrong:  0.000299019
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.964622484
p_ni:  0.035377477
p_wrong:  3.9e-8
Data Source:  BioPlex
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.956343398
p_ni:  0.001708005
p_wrong:  0.041948597
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.912487749
p_ni:  0.087502072
p_wrong:  0.000010179
Data Source:  BioPlex
MICB
Tbio
Novelty:  0.00364639
p_int:  0.876091182
p_ni:  0.003246059
p_wrong:  0.120662759
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
2
2
91.9
high density lipoprotein cholesterol measurement
3
2
3
87.5
fasting blood glucose measurement
6
1
6
77.9
3
3
2
1
71.4
body mass index
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
91.9
high density lipoprotein cholesterol measurement
3
87.5
fasting blood glucose measurement
6
77.9
2
1
71.4
body mass index
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 16
VGNC:1091
451150
Macaque
peroxisomal biogenesis factor 16
714904
Mouse
MGI:1338829
18633
Rat
RGD:1311372
311203
Dog
peroxisomal biogenesis factor 16
VGNC:44431
483639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 16
Macaque
peroxisomal biogenesis factor 16
Mouse
Rat
Dog
peroxisomal biogenesis factor 16
Publication Statistics
PubMed Score 37.28
PubMed score by year
PubTator Score 24.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title