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Tbio
PEX13
Peroxisomal membrane protein PEX13

Protein Summary
Description
Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. This gene encodes a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm. Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders, an example of which is Zellweger syndrome. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295030
  • ENSP00000295030
  • ENSG00000162928

Symbol
  • ZWS
  • NALD
  • PBD11A
  • PBD11B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.92
histone modification site profile
0.9
disease perturbation
0.83
transcription factor binding site profile
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
PEX7
Tbio
Novelty:  0.01487923
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999867317
p_ni:  0.000110549
p_wrong:  0.000022133
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.999856826
p_ni:  0.000143168
p_wrong:  5e-9
Data Source:  BioPlex
BTN3A2
Tbio
Novelty:  0.06889505
p_int:  0.998672596
p_ni:  0.000197934
p_wrong:  0.00112947
Score:  0.513
Data Source:  BioPlex,STRINGDB
ARHGEF39
Tdark
Novelty:  0.30447134
p_int:  0.994908754
p_ni:  0.000095426
p_wrong:  0.00499582
Data Source:  BioPlex
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.994860253
p_ni:  0.002188502
p_wrong:  0.002951245
Data Source:  BioPlex
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.974426059
p_ni:  0.002925365
p_wrong:  0.022648576
Score:  0.177
Data Source:  BioPlex,STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.959442507
p_ni:  0.00041863
p_wrong:  0.040138863
Data Source:  BioPlex
PEX14
Tbio
Novelty:  0.0210557
Score:  0.999
Data Source:  Reactome,STRINGDB
PEX12
Tbio
Novelty:  0.02252744
Score:  0.998
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Peroxisomal protein import
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Peroxisomal protein import
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
90.3
3
2
0
1.2
87.5
4
3
1
1.1
82
2
1
0
1.1
81.6
1
1
0
1.1
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.3
0
1.2
87.5
1
1.1
82
0
1.1
81.6
0
1.1
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 13
VGNC:334
470382
Macaque
peroxisomal biogenesis factor 13
717886
Mouse
MGI:1919379
72129
Rat
RGD:1310682
305581
Dog
peroxisomal biogenesis factor 13
VGNC:44430
474607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 13
Macaque
peroxisomal biogenesis factor 13
Mouse
Rat
Dog
peroxisomal biogenesis factor 13
Publication Statistics
PubMed Score 57.31
PubMed score by year
PubTator Score 26.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title