Tbio PEX11G Peroxisomal membrane protein 11C

Protein Summary

Description

Promotes membrane protrusion and elongation on the peroxisomal surface. The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96HA9
• Q8NDM0

Gene Name

• PEX11G

Ensembl ID

• ENST00000221480
• ENSP00000221480
• ENSG00000104883
• ENST00000593942
• ENSP00000472216

Symbol

• PEX11C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
cell type or tissue	0.84
cellular component	0.64
tissue sample	0.62
cell line	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.37   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.37   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

PEX11B

Tbio

Novelty:  0.04285427

Score:  0.975

Data Source:  STRINGDB

PEX11A

Tbio

Novelty:  0.01387985

Score:  0.971

Data Source:  STRINGDB

PEX3

Tbio

Novelty:  0.01171119

Score:  0.859

Data Source:  STRINGDB

SLC25A17

Tbio

Family:  Transporter

Novelty:  0.00601179

Score:  0.854

Data Source:  STRINGDB

PEX13

Tbio

Novelty:  0.01777214

Score:  0.841

Data Source:  STRINGDB

PEX10

Tbio

Novelty:  0.0174463

Score:  0.822

Data Source:  STRINGDB

PEX16

Tbio

Novelty:  0.03119723

Score:  0.799

Data Source:  STRINGDB

PEX12

Tbio

Novelty:  0.02252744

Score:  0.796

Data Source:  STRINGDB

PEX5

Tbio

Novelty:  0.00560901

Score:  0.782

Data Source:  STRINGDB

PEX7

Tbio

Novelty:  0.01487923

Score:  0.768

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Peroxisome	83 targets	path:hsa04146

Name	Explore in Pharos	Explore in Source
Peroxisome	83 targets	path:hsa04146

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (4)

Processes (2)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
intrinsic component of peroxisomal membrane	Inferred from Direct Assay (IDA)	UniProtKB
peroxisome	Inferred from Direct Assay (IDA)	UniProtKB
protein-containing complex	Inferred from Direct Assay (IDA)	UniProtKB
integral component of peroxisomal membrane	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	1	1	20		58.4
mean platelet volume	EFO_0004584	1	1	1		53.7
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		49.5
left ventricular structural measurement	EFO_0008205	3	1	3		49.5
opioid overdose severity measurement	EFO_0010140	1	1	1		31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	20		58.4
mean platelet volume	EFO_0004584	1		53.7
eosinophil percentage of leukocytes	EFO_0007991	1		49.5
left ventricular structural measurement	EFO_0008205	3		49.5
opioid overdose severity measurement	EFO_0010140	1		31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Membrane
Peroxisome
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
electrocardiography
eosinophil percentage of leukocytes
left ventricular structural measurement
mean platelet volume
opioid overdose severity measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	peroxisomal biogenesis factor 11 gamma	VGNC:2290	455654
Macaque	peroxisomal biogenesis factor 11 gamma		703198
Mouse	peroxisomal biogenesis factor 11 gamma	MGI:1920905	69129
Rat	peroxisomal biogenesis factor 11 gamma	RGD:1307070	288369
Dog	peroxisomal biogenesis factor 11 gamma	VGNC:44428	484992

Species	Name	OMA	EggNOG	Inparanoid
Chimp	peroxisomal biogenesis factor 11 gamma
Macaque	peroxisomal biogenesis factor 11 gamma
Mouse	peroxisomal biogenesis factor 11 gamma
Rat	peroxisomal biogenesis factor 11 gamma
Dog	peroxisomal biogenesis factor 11 gamma

Publication Statistics

PubMed Score 3.37

PubMed score by year

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PubTator Score 1.08

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title