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Tbio
PEX11A
Peroxisomal membrane protein 11A

Protein Summary
Description
May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455). This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300056
  • ENSP00000300056
  • ENSG00000166821
  • ENST00000561257
  • ENSP00000453492

Symbol
  • PEX11
  • PMP28
  • hsPEX11p
  • PEX11-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
histone modification site profile
0.86
virus perturbation
0.76
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.96251468
p_ni:  0.037485281
p_wrong:  3.9e-8
Score:  0.303
Data Source:  BioPlex,STRINGDB
PEX11G
Tbio
Novelty:  0.27261873
Score:  0.971
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.961
Data Source:  STRINGDB
FABP1
Tchem
Novelty:  0.00192691
Score:  0.951
Data Source:  STRINGDB
PEX3
Tbio
Novelty:  0.01171119
Score:  0.931
Data Source:  STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.923
Data Source:  STRINGDB
FIS1
Tbio
Novelty:  0.0033607
Score:  0.923
Data Source:  STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
Score:  0.903
Data Source:  STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.901
Data Source:  STRINGDB
CHD9
Tbio
Family:  Epigenetic
Novelty:  0.06234268
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
57.8
BMI-adjusted waist-hip ratio
1
1
1
51.4
mean corpuscular hemoglobin concentration
1
1
1
48.5
high density lipoprotein cholesterol measurement
1
1
1
48.5
electrocardiography
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
57.8
BMI-adjusted waist-hip ratio
1
51.4
mean corpuscular hemoglobin concentration
1
48.5
high density lipoprotein cholesterol measurement
1
48.5
electrocardiography
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 11 alpha
VGNC:14822
453641
Macaque
peroxisomal biogenesis factor 11 alpha
700511
Mouse
MGI:1338788
18631
Rat
RGD:619842
85249
Dog
peroxisomal biogenesis factor 11 alpha
VGNC:44426
100856425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 11 alpha
Macaque
peroxisomal biogenesis factor 11 alpha
Mouse
Rat
Dog
peroxisomal biogenesis factor 11 alpha
Publication Statistics
PubMed Score 90.62
PubMed score by year
PubTator Score 3.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title