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Tbio
PEX1
Peroxisome biogenesis factor 1

Protein Summary
Description
Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248633
  • ENSP00000248633
  • ENSG00000127980
  • ENST00000438045
  • ENSP00000410438

Symbol
  • ZWS
  • ZWS1
  • HMLR1
  • PBD1A
  • PBD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.96
histone modification site profile
0.92
cell type or tissue
0.78
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.6   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.6   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.982799573
p_ni:  0.017200427
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.959329473
p_ni:  0.040670527
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.951119525
p_ni:  0.048880475
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.946781008
p_ni:  0.053218992
Score:  0.185
Data Source:  BioPlex,STRINGDB
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.911499278
p_ni:  0.088500722
Score:  0.169
Data Source:  BioPlex,STRINGDB
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.879677218
p_ni:  0.120322782
Data Source:  BioPlex
FAS
Tbio
Novelty:  0.00043286
p_int:  0.779755727
p_ni:  0.220244273
Score:  0.163
Data Source:  BioPlex,STRINGDB
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
p_int:  0.776624005
p_ni:  0.223375995
Data Source:  BioPlex
PEX12
Tbio
Novelty:  0.02252744
Score:  0.993
Data Source:  Reactome,STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.993
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Peroxisomal protein import (R-HSA-9033241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
15
20
97.3
body height
3
3
3
97.2
leukocyte count
2
3
3
96.7
neutrophil count
2
3
3
94.7
basophil count
2
2
2
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
20
97.3
body height
3
97.2
leukocyte count
3
96.7
neutrophil count
3
94.7
basophil count
2
92.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 1
VGNC:4464
463532
Mouse
MGI:1918632
71382
Rat
RGD:1559939
500006
Dog
peroxisomal biogenesis factor 1
VGNC:54790
475227
Horse
peroxisomal biogenesis factor 1
VGNC:21318
100061418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 1
Mouse
Rat
Dog
peroxisomal biogenesis factor 1
Horse
peroxisomal biogenesis factor 1
Publication Statistics
PubMed Score 11.60
PubMed score by year
PubTator Score 92.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title