You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PES1
Pescadillo homolog

Protein Summary
Description
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335214
  • ENSP00000334612
  • ENSG00000100029
  • ENST00000354694
  • ENSP00000346725

Symbol
  • PES
  • NOP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
cellular component
0.81
disease perturbation
0.79
histone modification site profile
0.74
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.17   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.17   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (419)
BRD2
Tchem
Family:  Epigenetic
Novelty:  0.00531003
p_int:  0.999996208
p_ni:  0.000003792
Score:  0.429
Data Source:  BioPlex,STRINGDB
BOP1
Tbio
Novelty:  0.03512044
p_int:  0.999995997
p_ni:  0.000004003
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
WDR12
Tbio
Novelty:  0.03409059
p_int:  0.999989028
p_ni:  0.000010972
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PFKFB3
Tchem
Family:  Kinase
Novelty:  0.00333471
p_int:  0.999977139
p_ni:  0.000011736
p_wrong:  0.000011125
Score:  0.169
Data Source:  BioPlex,STRINGDB
NAF1
Tbio
Novelty:  2.99493689
p_int:  0.999919253
p_ni:  0.000078722
p_wrong:  0.000002024
Score:  0.856
Data Source:  BioPlex,STRINGDB
CWC22
Tbio
Novelty:  0.027689
p_int:  0.9998654
p_ni:  0.000134596
p_wrong:  4e-9
Score:  0.24
Data Source:  BioPlex,STRINGDB
UBTF
Tbio
Family:  TF
Novelty:  0.00421069
p_int:  0.999857189
p_ni:  0.000142811
Score:  0.376
Data Source:  BioPlex,STRINGDB
TRIM26
Tbio
Novelty:  0.07177119
p_int:  0.999509296
p_ni:  0.000490704
Data Source:  BioPlex
TNRC18
Tdark
Novelty:  0.32654022
p_int:  0.999505601
p_ni:  0.000494399
Data Source:  BioPlex
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
p_int:  0.999017611
p_ni:  0.000982389
Score:  0.253
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
93.1
mean reticulocyte volume
1
2
2
72.9
mean corpuscular volume
1
2
2
61.8
reticulocyte measurement
2
2
3
61.8
high density lipoprotein cholesterol measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
93.1
mean reticulocyte volume
2
72.9
mean corpuscular volume
2
61.8
reticulocyte measurement
3
61.8
high density lipoprotein cholesterol measurement
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pescadillo ribosomal biogenesis factor 1
VGNC:5292
458759
Macaque
pescadillo ribosomal biogenesis factor 1
718122
Mouse
MGI:1890613
64934
Rat
RGD:1559814
289740
Dog
pescadillo ribosomal biogenesis factor 1
VGNC:44425
486354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pescadillo ribosomal biogenesis factor 1
Macaque
pescadillo ribosomal biogenesis factor 1
Mouse
Rat
Dog
pescadillo ribosomal biogenesis factor 1
Publication Statistics
PubMed Score 15.17
PubMed score by year
PubTator Score 44.19
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title