Tdark PERM1 PGC-1 and ERR-induced regulator in muscle protein 1

Protein Summary

Description

Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.

Uniprot Accession IDs

• Q5SV97
• Q6ZVZ7
• Q9BRF2
• S5G239

Gene Name

• PERM1

Ensembl ID

• ENST00000341290
• ENSP00000343864
• ENSG00000187642
• ENST00000433179
• ENSP00000414022

Symbol

• C1orf170
• C1orf170

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.75
cell line	0.51
cellular component	0.44
biological process	0.43
cell type or tissue	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.16   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.16   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0