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Tbio
PELP1
Proline-, glutamic acid- and leucine-rich protein 1

Protein Summary
Description
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000574876
  • ENSP00000461625
  • ENSG00000141456

Symbol
  • HMX3
  • MNAR
  • MNAR
  • P160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
drug perturbation
0.87
cellular component
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.02   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.02   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (216)
WDR18
Tbio
Novelty:  0.03015818
p_int:  0.998994562
p_ni:  0.001005438
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
p_int:  0.99855643
p_ni:  0.00144357
Score:  0.998
Data Source:  BioPlex,STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.815285775
p_ni:  0.184714225
Score:  0.187
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.755542927
p_ni:  0.244457073
Score:  0.916
Data Source:  BioPlex,STRINGDB
LAS1L
Tbio
Novelty:  0.15470637
Score:  0.999
Data Source:  STRINGDB
TEX10
Tdark
Novelty:  0.12988812
Score:  0.996
Data Source:  Reactome,STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.995
Data Source:  STRINGDB
SENP3
Tbio
Family:  Enzyme
Novelty:  0.00374663
Score:  0.994
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.986
Data Source:  STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
PTK6 Expression
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
PTK6 Expression
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
7
10
99.3
eosinophil percentage of leukocytes
2
7
8
99.1
lymphocyte count
3
3
3
93.2
sum of eosinophil and basophil counts
1
3
3
93
C-X-C motif chemokine 16 measurement
1
2
2
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
10
99.3
eosinophil percentage of leukocytes
8
99.1
lymphocyte count
3
93.2
sum of eosinophil and basophil counts
3
93
C-X-C motif chemokine 16 measurement
2
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline, glutamate and leucine rich protein 1
VGNC:53299
454449
Macaque
proline, glutamate and leucine rich protein 1
677854
Mouse
MGI:1922523
75273
Rat
RGD:1306320
360552
Dog
proline, glutamate and leucine rich protein 1
VGNC:44417
479475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline, glutamate and leucine rich protein 1
Macaque
proline, glutamate and leucine rich protein 1
Mouse
Rat
Dog
proline, glutamate and leucine rich protein 1
Publication Statistics
PubMed Score 157.02
PubMed score by year
PubTator Score 75.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title